Colitis, Ulcerative Clinical Trial
Official title:
A Phase 1b, Exploratory Study to Assess the Safety, Tolerability, Colonic Tissue Exposure, and Anti-Inflammatory Effects of Two Different Doses of SRT2104 in Subjects With Mild to Moderate Ulcerative Colitis
The purpose of this research study is to:
- 1) Test the safety and tolerability of 2 different oral doses of SRT2104 in subjects
with ulcerative colitis
- 2) Determine the amount of SRT2104 measured from a single blood sample in addition to
colon and/or rectal tissue samples (biopsies)
- 3) Determine whether SRT2104 has any anti-inflammatory effect on the colon and/or
rectum when taken orally for 8 weeks
- 4) Determine whether SRT2104 causes any detectable changes to specific biomarkers. A
biomarker is a biological marker (or substance such as a protein) that is used as an
indicator of changes in a biological state that corresponds to the risk or progression
of a disease.
n/a
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