Cold Exposure Clinical Trial
Official title:
Effects of Winter Swimming on Blood Morphological, Rheological, and Biochemical Indicators and Oxidative Stress in Males
Verified date | January 2024 |
Source | University School of Physical Education, Krakow, Poland |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Exposure of the human body to cold water triggers numerous beneficial physiological changes. The study aimed to assess the impact of regular winter swimming on blood morphological, rheological, and biochemical indicators and activity of antioxidant enzymes in males. The study includes winter swimmers and a control group. Blood samples were taken twice - before the start (November) of the winter swimming season and after its end (March). The average duration of ice water baths was 3-5 minutes, with a minimum frequency of once a week. The water temperature during the swimming did not exceed 10°C, approaching 0°C during the winter period.
Status | Active, not recruiting |
Enrollment | 30 |
Est. completion date | December 31, 2024 |
Est. primary completion date | December 31, 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 25 Years to 60 Years |
Eligibility | Inclusion Criteria: - Good health, practitioners of winter swimming - control group: never did winter swimming and had a sedentary lifestyle. Exclusion Criteria: - medical contraindications to winter bathing |
Country | Name | City | State |
---|---|---|---|
Poland | University of Physical Education | Kraków |
Lead Sponsor | Collaborator |
---|---|
University School of Physical Education, Krakow, Poland |
Poland,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | blood sampling: platelets and leukocytes | Measurements of:
Platelets [thousands/µl], Leukocytes [thousands/µl], Neutrophils [thousands/µl], Eosinophils [thousands/µl], Basophils [thousands/µl], Lymphocytes [thousands/µl], Monocytes [thousands/µl]. |
twice: before the start of cold swimming in November and 5 months later (March), after the end of winter swimming | |
Primary | blood sampling: erythrocytes | Measurement of:
Erythrocytes [mln/µl], |
twice: before the start of cold swimming in November and 5 months later (March), after the end of winter swimming | |
Primary | blood sampling: haemoglobin | Determination of:
Haemoglobin [g/dl], mean corpuscular haemoglobin concentration (MCHC) [g/dl], |
twice: before the start of cold swimming in November and 5 months later (March), after the end of winter swimming | |
Primary | blood sampling: haematocrit | Determination of:
haematocrit [%], red blood cell distribution width coefficient of variation (RDW-CV) [%], |
twice: before the start of cold swimming in November and 5 months later (March), after the end of winter swimming | |
Primary | blood sampling: haemoglobin mass | Determination of:
mean corpuscular haemoglobin (MCH) [pg], |
twice: before the start of cold swimming in November and 5 months later (March), after the end of winter swimming | |
Primary | blood sampling: Erythrocytes | Determination of mean corpuscular volume (MCV) [fl], red blood cell distribution width standard deviation (RDW-SD) [fl], | twice: before the start of cold swimming in November and 5 months later (March), after the end of winter swimming | |
Primary | blood sampling: rheology part 1 | Determination of red cell elongation index (EI) [arbitrary unit: AU], erythrocyte aggregation amplitude (AMP) [AU], | twice: before the start of cold swimming in November and 5 months later (March), after the end of winter swimming | |
Primary | blood sampling: rheology part 2 | Determination of:
aggregation index (AI) [%], |
twice: before the start of cold swimming in November and 5 months later (March), after the end of winter swimming | |
Primary | blood sampling:rheology part 3 | Determination of:
half-time of total aggregation (t1/2) [s]. |
twice: before the start of cold swimming in November and 5 months later (March), after the end of winter swimming | |
Primary | blood sampling: oxidative stress | Measurement of catalase (CAT) [nmol/min/ml], and glutathione peroxidase (GPx) [nmol/min/ml]. | twice: before the start of cold swimming in November and 5 months later (March), after the end of winter swimming | |
Primary | blood sampling: oxidative stress - superoxide dismutase | Measurement of superoxide dismutase (SOD) [U/ml], | twice: before the start of cold swimming in November and 5 months later (March), after the end of winter swimming | |
Primary | blood biochemistry: Urea | Measurement of:
Urea [mmol/l]. |
twice: before the start of cold swimming in November and 5 months later (March), after the end of winter swimming | |
Primary | blood sampling: Testosterone | Determination of Testosterone concentration [ng/dl], | twice: before the start of cold swimming in November and 5 months later (March), after the end of winter swimming | |
Primary | blood sampling: Cortisol | Determination of Cortisol concentration [µg/dl], | twice: before the start of cold swimming in November and 5 months later (March), after the end of winter swimming | |
Primary | blood biochemistry: Creatine | Determination of Creatinine concentration [µmol/l], | twice: before the start of cold swimming in November and 5 months later (March), after the end of winter swimming |
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