Cold Exposure Clinical Trial
Official title:
Omega-3 Fatty Acid Modulation of Brown Adipose Tissue for Arctic Resilience
This clinical trial will assess the whether fish oil supplementation can modulate brown fat activation, shivering, thermal comfort and skin blood flow during cold exposure.
This proof-of-concept study will be conducted as a randomized, double-blind, placebo controlled, parallel group clinical trial in which 30 healthy men and women (ages 18-40 years) will be randomly assigned to fish oil (n=20; 7.8 g/day total n-3 PUFA: 3.75 g/day EPA and 1.5 g/day DHA) or placebo (n=20, olive oil) conditions for 12 weeks. Before beginning supplementation, and at 6- and 12-weeks post-supplementation, whole-body thermoregulation will be assessed by progressively reducing air temperature (from 29°C→4°C, with a wind speed of 4.5 m/s) over a 125-minute period in an environmental chamber. This approach will allow for quantitative determination of fish oil supplementation on body temperature regulation during cold exposure. This approach is novel because it also permits comprehensive assessment of the regulation of core body temperature (rectal temperature) and objective quantification of both autonomic [metabolic heat production (indirect calorimetry), BAT activation (infrared thermography), shivering (accelerometry, electromyography), skin blood flow (laser Doppler)] and behavioral (voluntary control of local thermal comfort) thermoregulatory responses. The advantage of this methodology is that this approach will enable assessment of whether fish oil supplementation is beneficial during exposure to cold environments. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Active, not recruiting |
NCT03541096 -
Winter-Swimming and Brown Adipose Tissue Activity in Middel-aged Obese Subjects (WinterBAT).
|
N/A | |
Recruiting |
NCT05584527 -
Assessment of the Effects of a 24-hour Cold and Heat Exposure on the Factors Influencing Food Intake
|
||
Not yet recruiting |
NCT06424132 -
Thermogenic Silencer Regulatory Factors in Humans
|
N/A | |
Completed |
NCT04738838 -
Oxytocin on Cold Water Task Performance and Recovery
|
Phase 2 | |
Completed |
NCT05107570 -
The Effect of Cold Exposure on Energy Expenditure
|
N/A | |
Completed |
NCT05894031 -
The Effectiveness of the Wim Hof Method
|
N/A | |
Completed |
NCT01483885 -
Comparison of the Analgesic Effects of Acupuncture and Modulated Electroanalgesia in Cold Induced Pain
|
Phase 1/Phase 2 | |
Recruiting |
NCT04359082 -
Cocoa-rich Bioflavanol Supplementation Effects During Cold Exposure
|
N/A | |
Recruiting |
NCT06159374 -
Effects of Physical Training in Altered Environmental Conditions on Exercise Performance
|
N/A | |
Active, not recruiting |
NCT06223087 -
Effects of Winter Swimming on Blood Indicators and Oxidative Stress in Males
|
||
Completed |
NCT05545943 -
Effects of Calorie Restriction and Cold Stimuli on Health-related Indicators, Cognitive and Motor Functions
|
N/A | |
Recruiting |
NCT05076357 -
Cold, Appetite and Weight Loss in Individuals With Obesity
|
N/A | |
Recruiting |
NCT05464758 -
The Effects of Cold Adaptation on Skin Blood Flow, Hand Function, and Comfort in Healthy Adults
|
N/A | |
Completed |
NCT03240497 -
Effects of Cold Exposure and Breathing Techniques on Immune Response
|
N/A |