Clinical Trials Logo
  1. Home
  2. Cold Exposure
  3. NCT05464758

The Effects of Cold Adaptation on Skin Blood Flow, Hand Function, and Comfort in Healthy Adults

Cold Exposure Clinical Trial

Official title:
The Effects of Cold Habituation on Peripheral Blood Flow, Hand Function, and Thermal Comfort

Clinical Trial Summary

In cold weather environments, blood flow to the extremities is significantly reduced, which severely impairs hand function and induces thermal discomfort. Prolonged or repeated cold exposure elicits an adaptive habituation response that is characterized by blunted skin vasoconstriction and thus may be an effective strategy to improve peripheral perfusion, reduce thermal discomfort, and maintain hand function during cold weather military operations. Since mission conditions often involve low ambient temperatures, countermeasures that reduce cold-induced decrements in hand function and thermal comfort are important to enhance Warfighter readiness in cold weather battlefield environments. The goals of this study are to 1) evaluate the effectiveness of cold habituation in improving skin blood flow, hand function, and thermal comfort during cold exposure and 2) identify the mechanisms that contribute to improvements in skin blood flow following habituation.

Clinical Trial Description

Participants (n=15, 18-39 yrs) will complete a preliminary cold air exposure (baseline testing) followed by 8 days of repeated cold air exposures with minimal clothing. The cold exposures will be 2 hours in duration and will be conducted in 8°C (46°F) conditions. Before and after the repeated cold exposures, participants will undergo hand function tests, assessments of thermal comfort, and skin blood flow testing. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05464758
Study type Interventional
Source United States Army Research Institute of Environmental Medicine
Contact Billie K Alba, Ph.D.
Phone 508-206-2171
Email billie.k.alba.civ@health.mil
Status Recruiting
Phase N/A
Start date August 1, 2022
Completion date September 30, 2024
View Details
See also
  Status Clinical Trial Phase
Active, not recruiting NCT03541096 - Winter-Swimming and Brown Adipose Tissue Activity in Middel-aged Obese Subjects (WinterBAT). N/A
Recruiting NCT05584527 - Assessment of the Effects of a 24-hour Cold and Heat Exposure on the Factors Influencing Food Intake
Not yet recruiting NCT06424132 - Thermogenic Silencer Regulatory Factors in Humans N/A
Completed NCT04738838 - Oxytocin on Cold Water Task Performance and Recovery Phase 2
Completed NCT05107570 - The Effect of Cold Exposure on Energy Expenditure N/A
Completed NCT05894031 - The Effectiveness of the Wim Hof Method N/A
Recruiting NCT05822141 - Omega-3 Fatty Acids as Regulators of Brown Adipose Tissue During Cold Exposure N/A
Completed NCT01483885 - Comparison of the Analgesic Effects of Acupuncture and Modulated Electroanalgesia in Cold Induced Pain Phase 1/Phase 2
Recruiting NCT04359082 - Cocoa-rich Bioflavanol Supplementation Effects During Cold Exposure N/A
Recruiting NCT06159374 - Effects of Physical Training in Altered Environmental Conditions on Exercise Performance N/A
Active, not recruiting NCT06223087 - Effects of Winter Swimming on Blood Indicators and Oxidative Stress in Males
Completed NCT05545943 - Effects of Calorie Restriction and Cold Stimuli on Health-related Indicators, Cognitive and Motor Functions N/A
Recruiting NCT05076357 - Cold, Appetite and Weight Loss in Individuals With Obesity N/A
Completed NCT03240497 - Effects of Cold Exposure and Breathing Techniques on Immune Response N/A