Cognitive Symptoms Clinical Trial
Official title:
The Neurobiology of Chemotherapy-Induced Cognitive Impairment
The investigators overall research hypothesis is that systemic chemotherapy induces
structural changes in the white matter of the brain as demonstrated with Diffusion Tensor
Imaging (DTI) and functional changes in well-defined cortical neural networks as
demonstrated by resting-state functional connectivity MRI (rs-fcMRI). The investigators
believe these structural and functional changes are responsible for the cognitive symptoms
associated with chemotherapy-induced cognitive impairment (CICI).
The Specific Aim for this study is:
To assess the impact of chemotherapy on structural white matter as defined by DTI and
functional cognitive networks as defined by rs-fcMRI by comparing a sample of breast cancer
survivors with self-reported CICI to breast cancer survivors without CICI.
Hypothesis: Post-chemotherapy breast cancer patients with self-reported CICI will have
abnormal structural connections characterized by DTI-defined disruptions in fractional
anisotropy (FA) and mean diffusivity (MD) and abnormal functional connectivity characterized
by rs-fcMRI-defined disruptions in cognitive networks when compared to patients without
self-reported CICI.
Chemotherapy has been linked to cognitive impairments among breast cancer patients, especially in the domains of executive function (planning and problem solving), attention, learning, and information processing. The etiology of these chemotherapy-associated impairments remains unknown, although recent neuroimaging studies suggest that disruption of white matter integrity may play a role. With continued use of chemotherapy in breast cancer patients, this study's novel use of functional neuroimaging will be significant to better inform practitioners and patients of potential consequences to anticipate and serve as a starting point in the development of therapeutic interventions. ;
Observational Model: Case Control, Time Perspective: Cross-Sectional
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