Preoperative Cognitive Impairment Predicts Postoperative Delirium

Cognitive Impairment Clinical Trial

Official title:

Preoperative Cognitive Impairment Predicts Postoperative Delirium in Elderly Patients Undergoing General Anesthesia

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05798767
• Other study ID #: PCI and POD
• Status: Completed
• Start date: February 1, 2022
• Est. completion date: March 1, 2023

Study information

• Verified date: January 2023
• Source: Henan Provincial People's Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Preoperative cognitive impairment (PCI) may increase the incidence of postoperative delirium (POD), yet screening for cognitive impairment is rarely performed. This study hypothesized that Mini-Cog for preoperative cognitive impairment screening predicts postoperative delirium. Elderly patients (65 years or older) attending Henan Provincial People's Hospital during the trial period who required elective thoracic surgery were recruited into the study.

Description:

We collected data points on demographics and hospital episodes through the electronic medical record the day before surgery. Cognitive function screening (Mini-Cog; the Mini-mental State Examination, MMSE), depression screening (Patient Health Questionnaire-9, PHQ-9), sleep quality assessment (Pittsburgh Sleep Quality Index, PSQI), and pain assessment (Numeric Rating Scale, NRS) were performed, and the time spent on Mini-Cog test and MMSE assessment was recorded. The Short Confusion Assessment Method (CAM) was administered once per day on postoperative days 1 to 5 to evaluate delirium.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 150
• Est. completion date: March 1, 2023
• Est. primary completion date: January 1, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 65 Years and older

Eligibility

Inclusion Criteria:

1. 65 years of age or older,

2. elective thoracic surgery,

3. under general anesthesia.

Exclusion Criteria:

1. history of psychiatric disorders,

2. use of any antipsychotic drugs,

3. ASA score >3

4. severe visual, hearing, or physical dysfunction unable to complete the scale

5. advanced malignant tumors of the chest with distant metastases to bone, liver, etc.,

6. history of general anesthesia surgery in the last six months.

Related Conditions & MeSH terms

• Cognitive Dysfunction
• Cognitive Impairment
• Delirium
• Delirium in Old Age
• Neurocognitive Disorders

Intervention

Behavioral:
• Neuropsychological tests
Cognitive function screening (Mini-Cog; the Mini-mental State Examination, MMSE), depression screening (Patient Health Questionnaire-9, PHQ-9), sleep quality assessment (Pittsburgh Sleep Quality Index, PSQI), and pain assessment (Numeric Rating Scale, NRS) were performed the day before surgery. The Short Confusion Assessment Method (CAM) was administered once per day on postoperative days 1 to 5 to evaluate delirium.

Locations

Country	Name	City	State
China	Henan People's Hospital	Zhengzhou

Sponsors (1)

Lead Sponsor	Collaborator
Henan Provincial People's Hospital

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	delirium	postoperative delirium accessed by the Short Confusion Assessment Method (CAM)	February 2022 to March 2023