Biomarkers Associated With Postoperative Cognitive Dysfunction

Status Recruiting

Clinical Trial Summary

Loss of cognitive function after major surgery is a significant risk in older people. It can occur acutely in the days after surgery as delirium or in months to years later as a persistent reduction in brain function termed neurocognitive decline. Together these conditions are called post operative cognitive dysfunction (POCD). They can be acutely distressing for patients and are associated with other problems after surgery. The causes of post operative cognitive dysfunction are poorly understood. Studies have been limited by a lack of biomarkers to predict which patients are at high risk of developing POCD. Research suggests silent strokes occurring during surgery and different sensitivities to anaesthetic medicines are associated with POCD. The project consists of a feasibility study to investigate markers that might predict people over 65 years old getting POCD. The first biomarker is a non-invasive monitor of anaesthetics effects on brain function called electroencephalography (EEG): The investigators will identify which EEG patterns predict delirium within five days surgery. The second set of biomarkers are two blood tests of proteins that increase after strokes: these are neurofilament light chains and tau proteins. The investigators will establish if these can be used to predict having POCD up to one year after surgery and long term cognitive impairment up to 5 years after surgery.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Cognitive Decline
Cognitive Dysfunction
Cognitive Impairment
Delirium
Postoperative Cognitive Complications
Postoperative Cognitive Dysfunction

Clinical Trial Details

NCT number	NCT05464355
Study type	Observational
Source	University of Oxford
Contact	Martyn Ezra
Phone	+44 1865572878
Email	martyn.ezra@ndcn.ox.ac.uk
Status	Recruiting
Phase
Start date	January 5, 2023
Completion date	November 2029

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