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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT03301402
Other study ID # 2017.304
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date September 22, 2017
Est. completion date January 5, 2021

Study information

Verified date May 2021
Source Chinese University of Hong Kong
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Background: There is epidemiological evidence or link ambient air pollution exposure to the incidence of dementia. Aims or hypotheses: It is hypothesized that reduction in indoor pollutants from air purification improves endothelial function and carotid intima thickness in older diabetic people with cognitive impairment. Subjects and method: People with clinically diagnosis mild cognitive impairment or early dementia will be recruited. After obtaining written consent, the subjects will be assessed cognitive function and arterial health. After baseline measurements, the subjects are randomly assigned to have either filter or no filter installed in the air purifier. The air purifier will be placed in living room of the household of the subject for one year. At one year, the measurements will be repeated. Statistical analysis: Intention to treat analysis will be adopted.


Recruitment information / eligibility

Status Completed
Enrollment 61
Est. completion date January 5, 2021
Est. primary completion date January 5, 2021
Accepts healthy volunteers No
Gender All
Age group 70 Years and older
Eligibility Inclusion Criteria: - Diabetic people - Mild cognitive impairment or early dementia Exclusion Criteria: - Current smoker - The presence of a smoker in the household - The absence of a reliable family caregiver - The lack of mental capacity to give informed consent

Study Design


Intervention

Device:
Air purifier
Air purifier with filter at automatic mode on all time

Locations

Country Name City State
Hong Kong The Chinese University of Hong Kong Hong Kong

Sponsors (1)

Lead Sponsor Collaborator
Chinese University of Hong Kong

Country where clinical trial is conducted

Hong Kong, 

Outcome

Type Measure Description Time frame Safety issue
Primary FMD% Endothelial function will be assessed by Flow mediated dilatation of brachial artery 12 months
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