Cognitive Impairment Clinical Trial
Official title:
Cognitive Impairment Following Sedation for Colonoscopy With Propofol, Midazolam and Fentanyl Combinations
Our hypothesis is that adding midazolam and/or fentanyl to propofol sedation for elective
outpatient colonoscopy increases cognitive impairment at hospital discharge without
improving intraoperative conditions or reducing intraoperative side-effects.
200 healthy patients aged 18 years or older will be randomised to receive propofol or
propofol plus midazolam and/or fentanyl. Cognitive impairment will be tested at hospital
discharge using Cogstate computerised testing software.
A great variety of drug combinations are administered to patients having elective outpatient colonoscopy. In addition, as patients are going home, some may have residual cognitive deficits that making leaving the hospital unsafe. This study aims to find drugs combinations that are associated with the least cognitive impairment. ;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Prevention
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