Cognitive Function 1, Social Clinical Trial
Official title:
Efficacy and Safety of Wheat Bran Extract on Improvement of Cognitive and Memory Function
The investigators performed a 12-week, randomized, double-blind, placebo-controlled human trial to evaluate the efficacy and safety of water extract from wheat Triticum aestivum L on cognitive and memory function. The investigators measured changes in cognitive function parameters, including CNT, WMT, K-MMSE, BCRS, PRMQ, PSS, SF-36 and BDNF
Based on reports about the neuroprotective effects of water extract from wheat Triticum
aestivum L. or its bran, the investigators hypothesize that extract of wheat bran (WBE) is
beneficial to elderly people with age-associated cognitive impairment. The investigators
investigated the efficacy and safety of WBE on improvement of cognitive function through
measuring the neuropsychometric assessments in adult with subjective cognitive impairment by
a randomized clinical trial.
Seventy participants aged from 50 to 80 years old with subjective cognitive impairment were
randomly assigned to receive either WBE (3,000 mg/day) in this 12-week, double-blind
placebo-controlled and parallel trial. Neuropsychological assessments including Computerized
Neurocognitive function test (CNT), Working Memory Test (WMT), Korean Mini-Mental State
Examination (K-MMSE), Brief Cognitive Rating Scale (BCRS), Prospective and Retrospective
Memory Questionnaire (PRMQ), Perceived Stress Scale (PSS), 36-Item of Short-Form Health
Survey (SF-36) and blood Brain-derived neurotrophic factor (BDNF) were used to assess the
cognitive function before and after the intervention.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention
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