Cognitive Dysfunction Clinical Trial
The purpose of this study is to determine whether the administration of physostigmine in combination with sedation for colonoscopy can minimize the cognitive decline at the time of hospital discharge
Physostigmine, a tertiary cholinesterase inhibitor, which prevents the breakdown of ACh by
inhibiting the enzyme acetylcholinesterase (AChE), crosses the blood-brain barrier (BBB),
and elevates brain ACh levels. Physostigmine has been shown to improve attention, and
performance in working memory. It has also been shown to produce analgesia following
systemic or central administration.
Patients undergoing colonoscopy under sedation of propofol and fentanyl show cognitive
decline in the immediate period following the procedure. In this study, half the patients
will receive physostigmine in combination with the sedation, and their cognitive functioning
at the time of hospital discharge will be assessed by standard neuropsychological tests, and
compared to that of patients without physostigmine.
;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Outcomes Assessor), Primary Purpose: Prevention
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