Cognitive Dysfunction Clinical Trial
The purpose of this study is to determine whether the administration of physostigmine in combination with sedation for colonoscopy can minimize the cognitive decline at the time of hospital discharge
Physostigmine, a tertiary cholinesterase inhibitor, which prevents the breakdown of ACh by
inhibiting the enzyme acetylcholinesterase (AChE), crosses the blood-brain barrier (BBB),
and elevates brain ACh levels. Physostigmine has been shown to improve attention, and
performance in working memory. It has also been shown to produce analgesia following
systemic or central administration.
Patients undergoing colonoscopy under sedation of propofol and fentanyl show cognitive
decline in the immediate period following the procedure. In this study, half the patients
will receive physostigmine in combination with the sedation, and their cognitive functioning
at the time of hospital discharge will be assessed by standard neuropsychological tests, and
compared to that of patients without physostigmine.
;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Outcomes Assessor), Primary Purpose: Prevention
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05273125 -
MOBility Disorders Assessment in Patients With Mild COGnitive Disorders
|
||
| Active, not recruiting |
NCT04049695 -
Improving Cognition After Cancer
|
N/A | |
| Completed |
NCT05912374 -
Adapting a Behavioral Intervention to Accommodate Cognitive Dysfunction in People Who Inject Drugs
|
N/A | |
| Recruiting |
NCT03977350 -
Association Between qEEG Measure and Post-Operative Cognitive Dysfunction (POCD) and Postoperative Delirium (POD)
|
||
| Not yet recruiting |
NCT06027632 -
Remotely Supervised Computerized Cognitive Stimulation to Reduce Post-chemotherapy Cognitive Difficulties in Patients Treated for Localized Breast Cancer
|
N/A | |
| Terminated |
NCT00754052 -
Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (Aricept) In The Treatment Of The Cognitive Dysfunction Exhibited By Children With Down Syndrome, Aged 11 To 17
|
Phase 3 | |
| Terminated |
NCT00754013 -
Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (Aricept) In The Treatment Of The Cognitive Dysfunction Exhibited By Children With Down Syndrome, Aged 6 To 10
|
Phase 3 | |
| Completed |
NCT00719628 -
Depth of Anaesthesia and Cognitive Dysfunction
|
N/A | |
| Recruiting |
NCT05014399 -
Cognitive Impairment in Colorectal Cancer Patients Receiving Cytotoxic Chemotherapy
|
||
| Completed |
NCT04966455 -
Effect of Raisins on Cognitive Function in Healthy Older Adults
|
Phase 3 | |
| Recruiting |
NCT05372159 -
Vanderbilt Memory and Aging Project
|
||
| Completed |
NCT03243279 -
BRS and Outcomes in Cardiothoracic Surgery
|
||
| Completed |
NCT04093882 -
The Relevance of the Blood-brain Barrier to Cognitive Dysfunction and Alzheimer's Disease
|
||
| Recruiting |
NCT05732285 -
A Pilot Randomized Controlled Trial: CoINTEGRATE
|
N/A | |
| Completed |
NCT06059768 -
Urdu Translation and Psychometric Analysis of Lawton IADLS.
|
||
| Completed |
NCT04624529 -
Validity and Reliability of a Self-evaluation Tool for Cognitive Deficits in the Acute Stage After Stroke
|
||
| Completed |
NCT04562662 -
Evaluation of mediVR-KAGURA Guided Therapy
|
N/A | |
| Not yet recruiting |
NCT04079075 -
Multiple Interventions to Prevent Cognitive Decline
|
N/A | |
| Active, not recruiting |
NCT04638101 -
Building the Path to Resilience in Preterm Infants: Mindfulness-based Intervention
|
N/A | |
| Active, not recruiting |
NCT04556305 -
Lifestyle Physical Activity and Cognitive Training Interventions
|
N/A |