Outcome
| Type |
Measure |
Description |
Time frame |
Safety issue |
| Other |
MOCA |
Montreal Cognitive Assessment, minimum score 0, maximum score 30, with higher scores indicating better cognitive performance |
baseline |
|
| Other |
Motivation to Change Lifestyle and Health Behavior for Dementia Risk Reduction scale |
scores range from 27-135, with higher scores indicating greater motivation to change |
2 years (measured at baseline, follow-up 1 and follow-up 2) |
|
| Primary |
2-year change from baseline in global cognitive composite score |
Global cognitive composite score derived from subtest scores from the Neuropsychological Test Battery (NTB) that includes 15-Word Verbal Learning Test delayed recall (discrete number; 0-15 (higher score means a better outcome)), Digit Symbol Substitution Test 90 seconds (discrete number; 0-90 (higher score means a better outcome)), WAIS digit span backwards (discrete number; 0-14 (higher score means a better outcome)), and semantic fluency (discrete number; 0-no maximum, higher score means a better outcome)). |
2 years (measured at baseline, follow-up 1 and follow-up 2) |
|
| Secondary |
15-Word Verbal Learning Test delayed recall |
discrete number; score: 0-15 (higher score means a better outcome) |
2 years (measured at baseline, follow-up 1 and follow-up 2) |
|
| Secondary |
Digit Symbol Substitution Test 90 seconds |
discrete number; 0-90 (higher score means a better outcome) |
2 years (measured at baseline, follow-up 1 and follow-up 2) |
|
| Secondary |
Wechsler Adult Intelligence Scale (WAIS) digit span backwards |
discrete number; 0-14 (higher score means a better outcome) |
2 years (measured at baseline, follow-up 1 and follow-up 2) |
|
| Secondary |
Semantic fluency |
word count in one minute; minimum 0, no maximum, higher score means a better outcome. |
2 years (measured at baseline, follow-up 1 and follow-up 2) |
|
| Secondary |
Instrumental activities of daily living using the Amsterdam Instrumental Activity of Daily Living Questionnaire (A-IADL-Q) |
Total scores range approximately 20-70, higher scores indicate better IADL functioning |
2 years (measured at baseline, follow-up 1 and follow-up 2) |
|
| Secondary |
5 level EuroQol-5D (EQ-5D-5L) |
Quality of life, score 0-100, higher scores indicate better quality of life |
2 years (measured at baseline, follow-up 1 and follow-up 2) |
|
| Secondary |
LIfestyle for BRAin health (LIBRA) |
Modifiable dementia risk using lifestyle for brain health; The score ranges from -5.9 (minimum score) to +12.7 (maximum score), with higher scores meaning a worse outcome (higher dementia risk) |
2 years (measured at baseline, follow-up 1 and follow-up 2) |
|
| Secondary |
grip strength test |
Scores between 0 to 90 kg can be measured on the Jamar Hand dynamometer, with higher scores indicating better grip strength |
2 years (measured at baseline, follow-up 1 and follow-up 2) |
|
| Secondary |
SQUASH questionnaire |
METs derived from the Ainsworth's compendium of physical activity will be used to classify physical activity intensity (<1.5METs- sedentary, 1.6-2.9 METs- light, 3.0-5.9METs- moderate, >6.0- vigorous physical activity). |
2 years (measured at baseline, follow-up 1 and follow-up 2) |
|
| Secondary |
LASA Sedentary Behavior Questionnaire |
Average hours and minutes of sedentary behavior a day, range from 0 to 24 hours. Higher scores (more hours) means a more sedentary behavior. |
2 years (measured at baseline, follow-up 1 and follow-up 2) |
|
| Secondary |
Pittsburgh Fatigability Scale |
Total physical and mental fatigability scores range from 0-50, with higher scores indicating higher fatigability. |
2 years (measured at baseline, follow-up 1 and follow-up 2) |
|
| Secondary |
SARC-F Sarcopenia Questionnaire |
sarcopenia, scores range from 0 to 10 (i.e. 0-2 points for each component; 0 = best to 10 = worst). |
2 years (measured at baseline, follow-up 1 and follow-up 2) |
|
| Secondary |
Five Facet Mindfulness Questionnaire - Short Form (FFMQ-SF) |
Total scale ranges from 24 - 120, higher scores indicate more mindfulness |
2 years (measured at baseline, follow-up 1 and follow-up 2) |
|
| Secondary |
Perceived Stress Scale |
Total score, scale 0 - 40, higher scores indicate more perceived stress |
2 years (measured at baseline, follow-up 1 and follow-up 2) |
|
| Secondary |
MetaMemory in Adulthood (MIA) |
Sum of Part 1 + Part 2A and B. Part 1: Strategy (scores 10 - 50, higher scores indicate more use of strategies), Part 2A: Subjective memory functioning, scores ranges from 23 - 115, with higher scores indicate better memory self-efficacy and 2B: Locus, scores ranges from 7 - 35, higher scores indicate better perceived personal control over remembering abilities. |
2 years (measured at baseline, follow-up 1 and follow-up 2) |
|
| Secondary |
Blood pressure |
scores range from approximately (for diastolic) 60-120 and (for systolic) 100-180 mmHg, with higher scores indicating higher blood pressure. |
2 years (measured at baseline, follow-up 1 and follow-up 2) |
|
| Secondary |
Cholesterol |
total (healthy level: 125 to 200mg/dL), HDL (healthy level = 40mg/dL or higher), LDL (healthy level = Less than 100mg/dL) + triglycerides (healthy level = less than 150-199 mg/dL) |
2 years (measured at baseline, follow-up 1 and follow-up 2) |
|
| Secondary |
Blood glucose |
HbA1C, scores range from approximately 30-100 mmol/mol, with higher scores indicate higher blood glucose levels. |
2 years (measured at baseline, follow-up 1 and follow-up 2) |
|
| Secondary |
Waist circumference |
measured in cm |
2 years (measured at baseline, follow-up 1 and follow-up 2) |
|
| Secondary |
Hip circumference |
measured in cm |
2 years (measured at baseline, follow-up 1 and follow-up 2) |
|
| Secondary |
Height |
measured in cm |
2 years (measured at baseline, follow-up 1 and follow-up 2) |
|
| Secondary |
Weight |
measured in kg |
2 years (measured at baseline, follow-up 1 and follow-up 2) |
|
| Secondary |
Hill-Bone Medication Adherence Scale |
scores range from 9-26, with lower scores indicating better medication adherence |
2 years (measured at baseline, follow-up 1 and follow-up 2) |
|
| Secondary |
MIND-adjusted Eetscore-FFQ |
Dutch Healthy Diet Index 2015 score (range 0-160 points, higher scores mean better outcome) and MIND score (range 0-15 points, higher scores mean better outcome), assessed by a short Food Frequency Questionnaire. |
2 years (measured at baseline, follow-up 1 and follow-up 2) |
|
| Secondary |
Nutritional intake |
Change in nutritional intake measured by an online 3-day food diary (assessed by Traqq application), qualitative assessment |
2 years (measured at baseline, follow-up 1 and follow-up 2) |
|
| Secondary |
Pittsburg Sleep Quality Index |
Total score ranging from 0 to 21 with the higher total score (referred to as global score) indicating worse sleep quality |
2 years (measured at baseline, follow-up 1 and follow-up 2) |
|
| Secondary |
Insomnia severity index |
The score ranges from 0 (minimum score) to 28 (maximum score), with lower scores indicating a better outcome |
2 years (measured at baseline, follow-up 1 and follow-up 2) |
|
| Secondary |
Lubben Social Network Scale |
The score ranges from 0 (minimum score) to 30 (maximum score), with higher scores meaning a better outcome (higher level of perceived social support) |
2 years (measured at baseline, follow-up 1 and follow-up 2) |
|
| Secondary |
De Jong Gierveldt Loneliness Scale |
The score ranges from 0 (minimum score) to 6 (maximum score), with higher scores representing a worse outcome (higher loneliness scores) |
2 years (measured at baseline and follow-up 2) |
|
| Secondary |
Aß42/40 ratio |
amyloid-ß (1-42)/(1-40) (pg/mL) |
2 years (measured at baseline and follow-up 2) |
|
| Secondary |
p-tau |
phosphorylated tau (pg/mL) |
2 years (measured at baseline and follow-up 2) |
|
| Secondary |
NfL |
neurofilament light chain (pg/mL) |
2 years (measured at baseline and follow-up 2) |
|
| Secondary |
GFAP |
glial fibrillary acidic protein (pg/mL) |
2 years (measured at baseline and follow-up 2) |
|
| Secondary |
BDNF |
brain-derived neurotrophic factor (pg/mL) |
2 years (measured at baseline and follow-up 2) |
|
| Secondary |
Actigraph (Groningen site only) |
physical activity, sedentary behavior and sleep-wake activity |
2 year (measured for 1 week at baseline, follow-up 1 and follow-up 2) |
|
| Secondary |
Physical Activity Record questionnaire (Groningen site only) |
physical activity, sedentary behavior and sleep-wake activity |
2 year (measured for 1 week at baseline, follow-up 1 and follow-up 2) |
|
