The Effect of Transcranial Direct Current Stimulation on Visual Attention - Single Sessions

Cognitive Decline Clinical Trial

Official title:

The Effect of Transcranial Direct Current Stimulation on Visual Attention - a Combined MRI and Non-invasive Brain Stimulation Single Session Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04134195
• Other study ID #: NV18-04-00256-single
• Status: Completed
• Phase: N/A
• Start date: February 19, 2020
• Est. completion date: December 30, 2020

Study information

• Verified date: September 2020
• Source: Masaryk University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Recently, attention has been drawn to non-invasive brain stimulation techniques, such as transcranial direct current stimulation (tDCS), in order to enhance cognitive functions by modifying brain plasticity and use it in different healthy and diseased populations. In the current research, investigator aim to examine the short-term effects of multiple tDCS protocols in healthy adults population on visual attention and identify the neural underpinnings of tDCS-induced behavioral aftereffects using a combined tDCS/ MRI network-based approach.

Description:

Investigator will investigate the shor-term effects of active tDCS as compared to a placebo stimulation on visual attention in the healthy seniors. A cross-over, randomized, placebo-controlled design will be used. Single tDCS sessions will be performed in 4 sessions over distinct brain areas with ongoing visual attention training. During the stimulation, investigator will use the visual matching task. MRI protocol consisting of T1 and resting state fMRI sequences will be acquired before and after every stimulation session in order to search for active vs. placebo tDCS-induced changes in brain activation and resting state functional connectivity and to identify neural correlates of behavioral changes.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 50
• Est. completion date: December 30, 2020
• Est. primary completion date: March 30, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• right handed, healthy volunteers in two groups - healthy adults under 40 years, healthy seniors over 50 years

Exclusion Criteria:

• psychiatric disorders, including major depression, major vascular lesions, and other brain pathologies detected by MRI that might present with cognitive decline

• a cardio pacemaker or any MRI-incompatible metal in the body

• epilepsy

• any diagnosed psychiatric disorder

• alcohol/drug abuse

• lack of cooperation

• presence of cognitive impairment

Related Conditions & MeSH terms

• Cognitive Change
• Cognitive Decline
• Cognitive Dysfunction
• Healthy Aging

Intervention

Device:
• Transcranial direct current stimulation
2mA stimulation for 20 minutes

Locations

Country	Name	City	State
Czechia	Ceitec, Masaryk University	Brno

Sponsors (2)

Lead Sponsor	Collaborator
Masaryk University	St. Anne's University Hospital Brno, Czech Republic

Country where clinical trial is conducted

Czechia, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Visual-attention task accuracy	Task will be presented on a computer and subject will respond by YES-NO buttons. Only if there are no differences in task accuracy, we will measure task reaction times (e.g. due to the roof effect).	Change from baseline immediately after completion of stimulation protocol
Primary	Magnetic resonance imaging	Investigator will record high resolution structural T1-weighted (MPRAGE) images, functional T2* weighted multiband EPI sequences. The total time spent in the scanner will be approximately 40 in every session.	Change from baseline immediately after completion of stimulation protocol