Study of Postoperative Cognitive Decline in Aged Patients

Cognitive Decline Clinical Trial

Official title:

Relationship Between Postoperative Cognitive Decline and Cytokines in Elderly Patients

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03765840
• Other study ID #: POCD-aged
• Status: Recruiting
• Start date: May 1, 2018
• Est. completion date: May 2021

Study information

• Verified date: December 2018
• Source: Changhai Hospital
• Contact: wenbin lu
• Phone: 86+21-31161841
• Email: 13004162573[@]163.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

postoperative cognitive decline is a common and deleterious complication in aged patients.The link between inflammation and postoperative cognitive decline has also been reported.However,the link between SOD1，SOD2，Osteopontin， Kallikrein-6，and Contactin-1 and postoperative cognitive decline is unknown. In this project ,investigators examine the relationship between 5 cytokines measured at there timepoints (preoperative [PREOP], postoperative day 1 [POD1] , and postoperative day 3[POD2]) and postoperative cognitive decline among older adults undergoing orthopedic surgery.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 300
• Est. completion date: May 2021
• Est. primary completion date: May 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 65 Years to 85 Years

Eligibility

Inclusion Criteria:

• patients who are more than 65 years old

• patients who undergo orthopedic surgery(trauma ,especially fracture of lower limb)

• patients with ASA physical status I-III

• patients who have a consent

Exclusion Criteria:

• patients who are more than 85 years old

• patients with ASA physical status >III

• patients who have neurological disorders, stroke or other affective central nervous system diseases

• patients who have a history of serious psychiatric illness

• patients with long-term use of psychoactive substances

• patients who undergo multiple trauma and the presence of head injury

Related Conditions & MeSH terms

• Cognitive Decline
• Cognitive Dysfunction

Locations

Country	Name	City	State
China	Deartment of anesthesiology,changhai hospital	Shanghai	Shanghai

Sponsors (1)

Lead Sponsor	Collaborator
Jia-feng Wang

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Differences in cytokines levels between the two groups	Compare differences in cytokines levels between the two groups	preoperation
Primary	Differences in cytokines levels between the two groups	Compare differences in cytokines levels between the two groups	24h after operation
Primary	Differences in cytokines levels between the two groups	Compare differences in cytokines levels between the two groups	72h after operation