Cognitive Decline Clinical Trial
Official title:
The Effect of Oral Vitamin B12 Supplementation on Cognitive Performance in Elderly People: the Brain12 Study
The purpose of this trial is to study the effects of oral vitamin B12 supplementation and vitamin B12 combined with folic acid supplementation on cognitive performance for 24 weeks in elderly people with mild vitamin B12 deficiency.
Mild vitamin B12 deficiency is highly prevalent in old age. Reasons for this high prevalence
are not fully understood, but include atrophic gastritis and bacterial overgrowth which
affect the absorption (active) of food-bound vitamin B12. In contrast, the ability to absorb
crystalline vitamin B12 (e.g. the form found in fortified foods or vitamin pills) remains
intact in old age. In both healthy and cognitively impaired elderly people, associations
between vitamin B12 status and cognitive performance have been observed, and the follow-up
of geriatric patients suggests effects of parenteral treatment in early cognitive
impairment.
We investigated whether daily oral supplementation with 1,000 μg vitamin B12 or 1,000 μg
vitamin B12 combined with 400 μg folate for 24 weeks improves cognitive performance in
people over 70 years with vitamin B12 deficiency.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Prevention
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03228446 -
The Effects of Attentional Filter Training on Working Memory
|
N/A | |
| Completed |
NCT04033419 -
Memantine for Prevention of Cognitive Decline in Patients With Breast Cancer
|
Phase 2 | |
| Terminated |
NCT05199142 -
A Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of SDI-118 in Elderly Male and Female Study Participants With Cognitive Decline
|
Phase 1 | |
| Active, not recruiting |
NCT05290233 -
Time Restricted Eating Plus Exercise for Weight Management
|
N/A | |
| Terminated |
NCT03337282 -
Incidence and Characteristics of Postoperative Cognitive Dysfunction in Elderly Quebec Francophone Patients
|
||
| Unknown status |
NCT00696514 -
Vitamin B12 and Folic Acid Supplementation for Preventing Fractures in Elderly People
|
Phase 1 | |
| Completed |
NCT00110604 -
The Effect of Folic Acid on Atherosclerosis, Cognitive Performance and Hearing
|
N/A | |
| Recruiting |
NCT06245005 -
Preoperative Cognitive Reserve in Older Surgical Patients: A Feasibility Study
|
||
| Recruiting |
NCT05014399 -
Cognitive Impairment in Colorectal Cancer Patients Receiving Cytotoxic Chemotherapy
|
||
| Active, not recruiting |
NCT05586750 -
Statins in Reducing Events in the Elderly Mind (STAREE-Mind) Imaging Substudy
|
Phase 4 | |
| Completed |
NCT04386902 -
Evaluation of Cognitive State Using Neurosteer EEG System
|
||
| Recruiting |
NCT06070818 -
Healthy Body & Mind Program for Older Adults Living With Osteoarthritis and Cognitive Decline
|
N/A | |
| Completed |
NCT01669915 -
A Large Randomized Trial of Vitamin D, Omega-3 Fatty Acids and Cognitive Decline
|
N/A | |
| Completed |
NCT02814526 -
Exercise in Adults With Mild Memory Problems
|
N/A | |
| Not yet recruiting |
NCT06252376 -
Effects of Blood Pressure on Cognition and Cerebral Hemodynamics in PD
|
N/A | |
| Not yet recruiting |
NCT05928078 -
A Home-based e-Health Intervention in the Elderly: MOVI-ageing
|
N/A | |
| Recruiting |
NCT06318377 -
Peanuts and Neurocognitive / Cardiovascular Health in Black Individuals
|
N/A | |
| Recruiting |
NCT03839784 -
Building a Platform for Precision Anesthesia in the Geriatric Surgical Patient
|
||
| Completed |
NCT04537728 -
My Healthy Brain: Preserving and Promoting Brain Health Through Evidence-based Practices
|
N/A | |
| Active, not recruiting |
NCT03370796 -
Group Reminiscence Therapy for Elderly People With Cognitive Decline in Institutional Context
|
N/A |