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Chronic Remote Ischemic Conditioning in Vascular Cognitive Impairment: A Dose Escalation Study

Cognition Disorder Clinical Trial

Official title:
Chronic Remote Ischemic Conditioning in Vascular Cognitive Impairment: A Dose Escalation Study

Clinical Trial Summary

To evaluate the dose-response of relevant blood biomarkers to remote ischemic conditioning in patients with age-related cerebral white matter hyperintensities on MRI, in preparation for a subsequent larger efficacy trial.

Clinical Trial Description

Objective: The objective of this early phase study is to evaluate the dose-response of relevant blood biomarkers to remote ischemic conditioning in preparation for a subsequent larger efficacy trial. In addition, we will evaluate the tolerability and adherence to the treatment protocol. Aim: We aim to measure blood biomarkers in response to daily remote ischemic conditioning (RIC) using a dose escalation study design in 40 patients with age-related cerebral white matter hyperintensities on MRI. Hypothesis: We hypothesize that there will be a significant change in the biomarker levels in a dose dependent fashion. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06179797
Study type Interventional
Source Augusta University
Contact Askiel Bruno, MD
Phone 706-721-1691
Email abruno@augusta.edu
Status Recruiting
Phase N/A
Start date August 15, 2020
Completion date December 15, 2023
View Details
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