Cognition Disorder Clinical Trial
Official title:
Facilitating Numerical Processing With Transcranial DC Stimulation in Developmental Dyscalculia
Verified date | July 1, 2011 |
Source | National Institutes of Health Clinical Center (CC) |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Background:
- Developmental dyscalculia is a learning disability in which individuals have difficulty
learning or comprehending mathematics or other number concepts (such as keeping score during
games, measuring time, or estimating distance). Developmental dyscalculia affects certain
parts of the brain that are required for processing numbers. Research has shown that a form
of brain stimulation called transcranial direct current stimulation (tDCS), applied when
healthy individuals are being trained to carry out tasks with numbers, improved the ability
to process numbers and solve math problems. More research is needed about whether tDCS can
improve number processing in people with developmental dyscalculia.
Objectives:
- To examine whether the effects of transcranial direct current stimulation can help
individuals with developmental dyscalculia perform mathematical calculations.
Eligibility:
- Individuals between 18 and 50 years of age who have been diagnosed with developmental
dyscalculia, or are healthy volunteers without dyscalculia.
Design:
- Participants will have a screening visit and seven study visits. The screening visit and
six of the study visits will take place consecutively over the course of 6 days, and the
final visit will take place 3 months after the initial participation.
- Participants will be screened with a medical history, physical and neurological
examination, and a brief examination to test for dyscalculia and determine the
participant's dominant hand.
- Participants will be randomly assigned to one of two groups for the study. One group
will receive tDCS during training to perform a task with numbers, and the other group
will receive the same training with sham stimulation. Participants will not know which
group they are in.
- During the study visits, participants will be trained on number tasks on 6 consecutive
days. Before the tDCS or sham stimulation is applied at the beginning of the experiment
and at the end of each training day, participants will perform other tasks with numbers.
Participants will be evaluated based on the accuracy and speed with which they respond
to the questions.
- At the followup visit, participants will perform the same number tasks they completed
during the study visits. No tDCS will be performed at this visit.
Status | Withdrawn |
Enrollment | 0 |
Est. completion date | July 1, 2011 |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 50 Years |
Eligibility |
- INCLUSION CRITERIA: We will include healthy volunteers and DD subjects who meet the following criteria: Age 18 to 50 years Able to provide informed consent No history of math difficulties as determined by Dyscalculia Screener examination > upper 50th percentile (healthy volunteers) Diagnosed with DD and scored < lower 25th percentile on Dyscalculia screening test (Developmental Dyscalculia subjects) Edinburgh handedness inventory shows a laterality index (LI) > 75 (dexterity) or LI of less than -75 (left-handedness) EXCLUSION CRITERIA: We will exclude healthy volunteers and DD subjects if one of the following conditions applies: Unable to perform the tasks due to visual problems History of seizures or brain tumor History of alcohol or drug abuse (defined as the use of a drug for a nontherapeutic effect ) or psychiatric illness such as severe depression History of brain surgery Drug treatment acting primarily on the central nervous system, which lowers the seizure threshold such as antipsychotic drugs (chlorprozamine, clozapine). Pregnancy |
Country | Name | City | State |
---|---|---|---|
United States | National Institutes of Health Clinical Center, 9000 Rockville Pike | Bethesda | Maryland |
Lead Sponsor | Collaborator |
---|---|
National Institute of Neurological Disorders and Stroke (NINDS) |
United States,
Cohen Kadosh R, Walsh V. Dyscalculia. Curr Biol. 2007 Nov 20;17(22):R946-7. — View Citation
Rubinsten O, Henik A. Developmental dyscalculia: heterogeneity might not mean different mechanisms. Trends Cogn Sci. 2009 Feb;13(2):92-9. doi: 10.1016/j.tics.2008.11.002. Epub 2009 Jan 8. Review. — View Citation
von Aster MG, Shalev RS. Number development and developmental dyscalculia. Dev Med Child Neurol. 2007 Nov;49(11):868-73. Review. — View Citation
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