Hepatic Encephalopathy Clinical Trial
Official title:
Impact of Coenzyme Q10 and Meclofenoxate on Frequency and Severity of Hepatic Encephalopathy
Hepatic encephalopathy is a syndrome occurs in patients with liver cirrhosis and is defined
as neuropsychiatric abnormalities in patients with liver impairment, characterized by
personality changes, intellectual impairment, and an impaired level of consciousness.
Coenzyme Q10 (CoQ10) is a necessary cofactor of the mitochondrial metabolism. It provides a
High antioxidant and protective effects on age-related morbidities such as hypertension,
heart failure and neurodegenerative diseases and hepatoprotective effects in drug related
hepatic impairment.
Meclofenoxate is a cholinergic nootropic drug used clinically to improve memory, mental
function and general cognition.
Hepatic encephalopathy is a syndrome occurs in patients with liver cirrhosis and is defined
as neuropsychiatric abnormalities in patients with liver impairment, characterized by
personality changes, intellectual impairment, and an impaired level of consciousness. Hepatic
encephalopathy is categorized into Type A hepatic encephalopathy associated with acute liver
failure; Type B hepatic encephalopathy is associated with portal-systemic bypass and no
intrinsic hepatocellular disease; Type C hepatic encephalopathy describes encephalopathy
associated with Cirrhosis and portal hypertension; type C hepatic encephalopathy is, in turn,
subcategorized as episodic, persistent, or minimal.
A number of theories had been postulated, it was proposed that hepatic encephalopathy is a
disorder of astrocyte function which play a key role in the regulation of the blood-brain
barrier, maintaining electrolyte homeostasis , a role in the detoxification of chemicals,
including ammonia.
neurotoxic substances, including ammonia and manganese cause morphologic changes in the
astrocytes leading to Alzheimer type II astrocytosis in cirrhosis.
Hepatic encephalopathy may be due to accumulated neurotoxic substances in the brain as
short-chain fatty acids; mercaptans; false neurotransmitters, such as tyramine, octopamine,
and beta-phenylethanolamines; manganese; ammonia; and gamma-aminobutyric acid (GABA).
Coenzyme Q10 (CoQ10) is a necessary cofactor of the mitochondrial metabolism. It provides a
High antioxidant and protective effects on age-related morbidities such as hypertension,
heart failure and neurodegenerative diseases and hepatoprotective effects in drug related
hepatic impairment.
Meclofenoxate is a cholinergic nootropic drug used clinically to improve memory, mental
function and general cognition.
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