Targeting Drug Memories With Methylphenidate

Status Recruiting

Clinical Trial Summary

This study aims to identify the neural, behavioral, and pharmacological mechanisms promoting diminished expression of drug-related memories in human drug addiction. In this fMRI study with a within-subjects placebo-controlled double-blind cross-over design, oral methylphenidate (20 mg) or placebo will be administered to individuals with cocaine use disorders (CUD) to peak during the retrieval of a drug-cue memory before extinction; in addition to fMRI activations, skin conductance responses (SCR, acquired simultaneously) will serve as the psychophysiological indicators of memory modification. Assessments of interference with the return of drug-cue memories via SCR and craving will be conducted the day following MRI. This pharmocologically-enhanced behavioral approach to decreasing drug memories and craving in iCUD could ultimately be used to develop effective cue-exposure therapies for drug addiction. Procedures include MRI, blood draw, questionnaires and interviews, skin conductance response measures, and behavioral tasks.

Clinical Trial Description

Cue-exposure therapy has not proven efficacious in reducing relapse in drug addiction, illuminating the need for alternative strategies. Here researchers will test the neural correlates of two strategies, encompassing behavioral and pharmacological approaches, aimed to interfere with the return of drug memories in individuals with cocaine use disorders. Results may pave the way towards enhancing the efficacy of cue-exposure therapy in reducing cue-induced craving and relapse in drug addiction (generalizable across drugs of abuse/behavioral addictions). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05978167
Study type	Interventional
Source	Icahn School of Medicine at Mount Sinai
Contact	Kathryn Drury, B.M.
Email	kathyrn.drury@mssm.edu
Status	Recruiting
Phase	Early Phase 1
Start date	July 5, 2023
Completion date	August 31, 2024

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03538548` - Treatment Outcome in CBT for Cocaine Use	N/A
Recruiting	`NCT04994821` - tDCS to Reduce Craving in Cocaine Addiction- Phase 2 Study	Phase 2
Not yet recruiting	`NCT06050304` - CRACK-TARGET 1: ÉTUDE DESCRIPTIVE DE LA SENSIBILISATION COMPORTEMENTALE OBSERVÉE et ATTENTES
Completed	`NCT02239913` - Topiramate-Phentermine Combinations for Cocaine Dependence	Phase 1
Completed	`NCT02233647` - Phendimetrazine and Cocaine	Early Phase 1
Not yet recruiting	`NCT05974202` - rTMS and Cognitive-behavioral Therapy for Cocaine Use Disorder	Phase 2
Recruiting	`NCT04927143` - Encouraging Abstinence Behavior in a Drug Epidemic	Phase 2
Completed	`NCT03224546` - Cocaine Use Reduction and Health	N/A
Recruiting	`NCT03656653` - Imagery-based Coping for Cocaine Use Disorder	N/A
Completed	`NCT03348384` - [11C]NOP-1A and Cocaine Use Disorders	Early Phase 1
Recruiting	`NCT05019430` - Cocaine and Zolmitriptan	Early Phase 1
Recruiting	`NCT03344419` - Glutamatergic Modulation to Facilitate the Behavioral Treatment of Cocaine Use Disorders	Phase 3
Recruiting	`NCT05507814` - Temporal Window and Episodic Future Thinking in CUD	N/A
Active, not recruiting	`NCT03799341` - Neurocognitive Factors in Substance Use Treatment Response: The Ways of Rewarding Abstinence Project	N/A
Completed	`NCT02798627` - Trial Of NS2359 For The Treatment of Cocaine Dependence	Phase 2
Completed	`NCT02785406` - Role of the Orexin Receptor System in Stress, Sleep and Cocaine Use	Phase 2
Completed	`NCT02444208` - A Feasibility Trial for Inhibitory-Control Training to Reduce Cocaine Use	N/A
Recruiting	`NCT05902819` - Reconsolidation Blockade of Intrusive Trauma- and Cocaine-related Memories	N/A
Recruiting	`NCT05521854` - Contingency Management for Drug Use: Does Age Matter?	N/A
Recruiting	`NCT05833529` - Innovative Cognitive and Behavioral Psychotherapy for Cocaine Use Disorder	N/A