Innovative Cognitive & Behavioral Psychotherapy for Cocaine Use Disorder

Status Recruiting

Clinical Trial Summary

Cocaine is the 2nd most used illicit substance in Europe and its use implies numerous health complications as well as an annual social cost of 8.7 G d'€. Classical (picture, video, audio, imagery based or in vivo) cue exposure therapy for substance craving (CET), i.e. the irrepressible and non-voluntary desire to use the substance, failed to prove efficacious in treating substance use disorder. Virtual reality cue exposure therapy for substance craving (VRCET), is more immersive, realistic and controllable, and is suggested as being a more efficacious intervention in reducing craving as compared to classical CET. So far it's still not known, thus the secondary aim of the present randomized and clinical trial is to investigate, whether virtual reality cue exposure is more efficacious, as compared to classical cue exposure, in both eliciting and reducing cocaine craving in a clinical context of CET for cocaine craving. The main study aim to is to investigate whether a VRCET for cocaine craving based cognitivo-behavioral therapy (i.e. VRCET followed by memory focused cognitive therapy) is more efficacious than a behavioural therapy (i.e. classical exposure therapy to craving) in reducing cocaine craving. To do so, 54 voluntary residential patients in treatment for cocaine use disorder will be recruited from the Universitary Hospital Center of Martinique (CHUM, Martinique, France) and Saint-Esprit Hospital Center (CHSE, Martinique, France) and randomly allocated in either a 3 weeks individual experimental treatment (10 meetings of VRET for cocaine craving followed by 5 meetings of memory focused cognitive therapy) or a 3 weeks individual control treatment (15 meetings of pictures based exposure therapy for cocaine craving). Self-reported measures of retrospective (last 14 days) and in virtuo exposure cocaine craving will be collected at the beginning, after 10 days, after 15 days of treatment and 1 month post. Others secondary subjective, urinary and physiological cocaine use related measures will also be collected.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Cocaine Use Disorder

Clinical Trial Details

NCT number	NCT05833529
Study type	Interventional
Source	University Hospital Center of Martinique
Contact	Thomas LEHOUX, Ph.D. Candidate
Phone	06 66 33 78 41
Email	thomas.lehoux@hotmail.fr
Status	Recruiting
Phase	N/A
Start date	May 1, 2023
Completion date	May 2025

View Details

See also
Status	Clinical Trial	Phase
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Completed	`NCT02798627` - Trial Of NS2359 For The Treatment of Cocaine Dependence	Phase 2
Completed	`NCT02785406` - Role of the Orexin Receptor System in Stress, Sleep and Cocaine Use	Phase 2
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Recruiting	`NCT05902819` - Reconsolidation Blockade of Intrusive Trauma- and Cocaine-related Memories	N/A
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Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Innovative Cognitive and Behavioral Psychotherapy for Cocaine Use Disorder — PICOC

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms