Outcome
Type |
Measure |
Description |
Time frame |
Safety issue |
Primary |
Amplitude of the Reward Potential (RewP) in Microvolts in Response to Feedback on the Doors Task as Assessed by EEG |
The Doors Task will be used to elicit the Reward Potential (RewP) component, representing reward sensitivity. The task is a guessing game, where participants guess which door contains a reward behind it. After selecting a door, the participants are notified if they found the prize by a green arrow pointing up or if they did not find the prize by a red arrow pointing down. The amplitude of the RewP in microvolts in response to feedback is reported. |
Baseline (before iTBS session) |
|
Primary |
Amplitude of the Reward Potential (RewP) in Microvolts in Response to Feedback on the Doors Task as Assessed by EEG |
The Doors Task will be used to elicit the Reward Potential (RewP) component, representing reward sensitivity. The task is a guessing game, where participants guess which door contains a reward behind it. After selecting a door, the participants are notified if they found the prize by a green arrow pointing up (win) or if they did not find the prize by a red arrow pointing down (loss). The amplitude of the RewP in microvolts in response to feedback is reported. |
Immediately after iTBS session |
|
Primary |
Amplitude of the Late Positive Potential (LPP) in Microvolts in Response to Visual Stimuli on the Picture Viewing Task as Assessed by EEG |
The Picture Viewing Task will be used to elicit the late positive potential (LPP), reflecting the motivational salience of a stimulus. During this task, participants are asked to view a slideshow of images including pleasant, unpleasant, neutral, and cocaine-related images. The amplitude of the LPP in microvolts in response to visual stimuli is reported. |
Baseline (before iTBS session) |
|
Primary |
Amplitude of the Late Positive Potential (LPP) in Microvolts in Response to Visual Stimuli on the Picture Viewing Task as Assessed by EEG |
The Picture Viewing Task will be used to elicit the late positive potential (LPP), reflecting the motivational salience of a stimulus. During this task, participants are asked to view a slideshow of images including pleasant, unpleasant, neutral, and cocaine-related images. The amplitude of the LPP in microvolts in response to visual stimuli is reported. |
Immediately after iTBS session |
|
Secondary |
Craving as Assessed by the Minnesota Cocaine Craving Scale (MCCS) |
The first question (intensity of craving) will be used and is measured from 0(none, not at all) to 100(a great deal), higher number indicating more craving. |
Baseline(before iTBS session) |
|
Secondary |
Craving as Assessed by the Minnesota Cocaine Craving Scale (MCCS) |
The first question (intensity of craving) will be used and is measured from 0(none, not at all) to 100(a great deal), higher number indicating more craving. |
Immediately after iTBS session |
|
Secondary |
Pain as Assessed by the Visual Analog Scale (VAS) |
This is scored from 0(no pain) to 10 (worst pain), higher score indicating greater pain. |
Baseline(before iTBS session) |
|
Secondary |
Pain as Assessed by the Visual Analog Scale (VAS) |
This is scored from 0(no pain) to 10 (worst pain), higher score indicating greater pain. |
Immediately after iTBS session |
|
Secondary |
Cognitive Function as Assessed by the Montreal Cognitive Assessment (MoCA) |
Total score on the Montreal Cognitive Assessment (MoCA) range from 0 to 30, with a higher score indicating a better outcome. |
Baseline(before iTBS session) |
|
Secondary |
Cognitive Function as Assessed by the The Montreal Cognitive Assessment (MoCA) |
Total score on the Montreal Cognitive Assessment (MoCA) range from 0 to 30, with a higher score indicating a better outcome. |
Immediately after iTBS session |
|