Cocaine Dependence Clinical Trial
Official title:
Brain Function and Structure in Cocaine Dependence
The purpose of this study is to examine the role of brain MRI findings in predicting treatment outcomes among individuals with cocaine dependence.
The Specific Aims of this project are:
Aim 1: To determine whether pretreatment brain activation on fMRI while performing a Go-Nogo
task predicts response to pharmacotherapy in cocaine dependent subjects.
Hypothesis related to Aim 1:
Pretreatment fMRI BOLD activation in cocaine dependent subjects during impulsive responding
on the Go-Nogo task predicts 8-week outcome from medication known to enhance serotonin
function (citalopram). The regression coefficient of TES on pretreatment mean BOLD activation
on the Go-Nogo task will be significantly greater for the citalopram group than the placebo
group.
Aim 2: To determine whether pretreatment brain activation on fMRI while performing an
attentional bias (cocaine Stroop) task predicts response to pharmacotherapy in cocaine
dependent subjects.
Hypothesis related to Aim 2:
Pretreatment fMRI BOLD activation in cocaine dependent subjects during cocaine related words
on the cocaine Stroop task predicts 8-week outcome from medication known to enhance serotonin
function (citalopram). The regression coefficient of TES on pretreatment mean BOLD activation
from the cocaine Stroop task will be significantly greater for the citalopram group than the
placebo group.
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