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Pharmacotherapy & CM for Opioid and Cocaine Dependence

Cocaine Dependence Clinical Trial

Official title:
Pharmacotherapy & CM for Opioid and Cocaine Dependence

Clinical Trial Summary

The purpose of this study is to compare the efficacy of the combined treatment modafinil + Contingency Management (CM) to either treatment condition alone or to yoked-controls on cocaine abstinence. To investigate the role of modafinil-related improvements in memory, impulse control, and attention in mediating cocaine abstinence.

Clinical Trial Description

We hypothesize that the treatment group receiving the combination of modafinil + Contingency Management will have significantly lower cocaine use than the other treatment conditions. We also hypothesize that improvements in memory, impulse control, and attention will be a significant contributor to the treatment improvements investigated in Specific Aim #1. Opioid and cocaine dependence are major problems among veteran and non-veterans and no effective pharmacotherapy exists for cocaine dependence. Methadone has not shown robust effectiveness in reducing cocaine abuse. Thus, new treatments are needed for the individuals who have developed cocaine dependence. This study is designed to test a new pharmacotherapy for cocaine dependence and is a placebo-controlled trial. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00838981
Study type Interventional
Source Yale University
Contact
Status Completed
Phase Phase 1/Phase 2
Start date May 2008
Completion date March 2014
View Details
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