Prize Contingency Management for Cocaine-Dependent Methadone Patients

Cocaine Abuse Clinical Trial

Official title:

Prize Contingency Management for Cocaine-Dependent Methadone Patients

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01401270
• Other study ID #: 10-256-2
• Secondary ID: R01DA013444
• Status: Completed
• Phase: N/A
• Start date: November 2011
• Est. completion date: May 2018

Study information

• Verified date: March 2019
• Source: UConn Health
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The investigators will randomize 300 cocaine-dependent methadone patients to 1 of 6 conditions: (a) a control group, (b) a contingency management condition that arranges a 100% probability of winning a prize with each draw and has 3 prize categories, (c) a contingency management condition that arranges a 31% probability of winning and has 3 prize categories, (d) a contingency management condition that arranges a 100% probability of winning and has 7 prize categories, (e) a contingency management condition that arranges a 31% probability of winning and has 7 prize categories, or (f) usual prize contingency management with a 50% probability of winning from 3 prize categories. Magnitudes of reinforcement will be identical across conditions, but lower overall probability conditions arrange for greater chances of winning larger magnitude prizes. The investigators expect that the new contingency management conditions will reduce cocaine use relative to the control condition, that 31% probability conditions will decrease drug use relative to 100% conditions, and that 7-prize category conditions will reduce drug use compared to 3-prize category conditions. In addition, the 31%/7-category condition is expected to be most efficacious. Results will be instrumental for further developing prize contingency management to improve outcomes of cocaine-dependent methadone patients.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 280
• Est. completion date: May 2018
• Est. primary completion date: May 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• age > 18 years

• current DSM-IV diagnosis of cocaine dependence

• enrolled at the clinic for >3 months

• on a stable dose of methadone (no changes) for >1 month and not requesting a dose alteration

• submitted >1 clinic cocaine positive sample in the last 6 months

• English speaking

• pass a quiz related to understanding the informed consent form

Exclusion Criteria:

• serious, uncontrolled psychiatric illness

• significant cognitive impairment

• in recovery from pathological gambling

Related Conditions & MeSH terms

• Cocaine Abuse
• Cocaine-Related Disorders

Intervention

Behavioral:
• prize contingency management
Participants earn the chance to win prizes for the targeted behavior, cocaine abstinence.

Locations

Country	Name	City	State
United States	University of Connecticut Health Center	Farmington	Connecticut

Sponsors (2)

Lead Sponsor	Collaborator
UConn Health	National Institute on Drug Abuse (NIDA)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	longest continuous period of cocaine abstinence		three months