The Effect of Human Prostate Tissue on Platelet Activation

Status Completed

Clinical Trial Summary

Transurethral resection of the prostate (TURP) is a common and standard urological surgical procedure for managing benign prostatic hyperplasia (BPH). Although surgical technology improved in recent decades, severe complications such as TURP syndrome, hematuria, and postoperative hemorrhage were still considerable. Coagulopathy is one of rare but devastating complication which may contribute to bleeding during and after TURP. Although the exact pathophysiological condition of coagulopathy is not clear, there are several possible mechanisms of TURP associated coagulopathy including: urokinase- (u-PA) and tissue-type plasminogen activator (t-PA)-related fibrinolysis; absorption of irrigating fluid associated dilutional coagulopathy; release of prostatic particles rich in tissue thromboplastins into the circulation causing secondary ﬁbrinolysis and disseminated intravascular coagulopathy (DIC); sepsis with DIC associated with bacteria entering the circulation due to prostatic venous sinuses opening and the using of high pressure irrigation. On the other hand, platelet are essential to hemostasis and thrombosis and its activation also contributes to leukocyte recruitment and DIC. Furthermore, previous studies demonstrated that activated platelets could express TLR4, CD40L, P-selectin and induce platelet-leukocyte aggregation (PLA), which were considered important for systemic inflammatory responses and DIC development. Currently, no study investigating the association of prostate particle and platelet activation. Here, we tested the hypothesis that prostate tissue may induce inflammatory responses through platelet activation by measuring the expression of TLR4, CD40L, P-selectin and PLA on platelets.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05059431
Study type	Observational
Source	Tri-Service General Hospital
Contact
Status	Completed
Phase
Start date	February 4, 2015
Completion date	April 24, 2017

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05443451` - BETTY: BEnign Prostatic Hyperplasia Transperineal Targeted Microwave therapY	N/A
Recruiting	`NCT04288427` - 5-Alpha Reductase 2 as a Marker of Resistance to 5ARI Therapy	N/A
Not yet recruiting	`NCT05017285` - Ejaculation Preservation After Laser Enucleation Prostate	N/A
Completed	`NCT02778243` - Sexual Steroids: Relationship Between Serum and Prostatic Tissue Level	N/A
Completed	`NCT04212403` - Antibiotic Prophylaxis in Transurethral Prostate Resection (TURP) and Transurethral Bladder Tumour Resection (TURB)	N/A
Recruiting	`NCT05440981` - Implanted Nitinol Device (iTind) System in Chinese Males With Lower Urinary Tract Symptom Secondary to BPH	N/A
Recruiting	`NCT05531240` - Transurethral Prostate Resection (TURP) vs. Prostate Artery Embolization (PAE)	N/A
Recruiting	`NCT03176017` - Ejaculatory Sparing Transurethral Incision Of The Prostate (ES-TUIP) Versus Conventional TUIP	N/A
Completed	`NCT02244294` - FLOMAX® Versus Placebo, in Male Patients With Acute Urinary Retention Related to Benign Prostatic Hyperplasia (BPH)	Phase 2
Recruiting	`NCT03966950` - Use of Melatonin for Preventing POCD in Transurethral Prostate Resection Under Spinal Anesthesia	N/A
Enrolling by invitation	`NCT06469125` - Anatomic Endoscopic Prostate Enucleation and BICEP Classification
Recruiting	`NCT06116851` - Prostate Metabolism, Cancer Risk and Gut Microbiota
Completed	`NCT04781985` - Prostatic Resection Cavity Stone Post Transurethral Resection of the Prostate (TURP). A Rare Case Scenario	N/A
Not yet recruiting	`NCT01876836` - Clasic Laryngeal Mask Airway(C-LMA) and I-gel Releated Regurgitation and Complications	Phase 4
Completed	`NCT05941260` - Standardization of Prostatic Resection by Virtual Computational Reconstruction and Computational Flow Dynamics
Completed	`NCT04580628` - Thuflep/SOLEP : Initial Experience and Results of Prostate Laser Enucleation With Thulium-fiber Laser (TFL)
Completed	`NCT04848181` - The Effect of Pre-operative Use of Finasteride Versus Cyproterone Acetate on Blood Loss With Transurethral Resection of Prostate	Early Phase 1
Recruiting	`NCT06224218` - Prostate Single Port & Laser Enucleation Comparison Trial	N/A
Completed	`NCT04781049` - Transperineal Laser Ablation vs Transurethral Resection for Benign Prostatic Obstruction: A Randomized Clinical Trial	N/A
Completed	`NCT05108662` - Inflammatory Markers: HOLEP Versus TURP	N/A