Metastatic Melanoma Clinical Trial
Official title:
Procurement of Central Nervous System and Extracranial Tumor Tissues, Cerebrospinal Fluid, and Serum/Plasma From Patients With Metastatic Melanoma to the CNS and Respective Controls for Gene Expression and Proteomic Profiling
This study has two ultimate goals:
1. Understand how the original melanoma from the skin spreads to the CNS. In order to
study this we need to collect (and compare) the original skin melanoma, the CNS
melanoma, as well as any other melanoma that has not metastasized to the CNS.
2. Develop a diagnostic blood test that will early identify subjects at high risk for
developing CNS metastasis or patients who may already have CNS metastasis but the MRI
or the CAT scan cannot yet detect it. Thus, the investigators plan to collect CSF from
subjects like you who have melanoma CNS metastases in order to confirm the presence of
this biomarker.
n/a
Observational Model: Case Control, Time Perspective: Prospective
Status | Clinical Trial | Phase | |
---|---|---|---|
Active, not recruiting |
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|
Phase 3 | |
Active, not recruiting |
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Phase I, Open-Label, Study of Tumor Infiltrating Lymphocytes Engineered With Membrane Bound IL15 Plus Acetazolamide in Adult Patients With Metastatic Melanoma
|
Phase 1 | |
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E6201 and Dabrafenib for the Treatment of Central Nervous System Metastases From BRAF V600 Mutated Metastatic Melanoma
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Phase 1 | |
Active, not recruiting |
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Phase 1 | |
Completed |
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|
Phase 4 | |
Completed |
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Phase 1 | |
Completed |
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Phase 1 | |
Recruiting |
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Phase 2 | |
Active, not recruiting |
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Tocilizumab, Ipilimumab, and Nivolumab for the Treatment of Advanced Melanoma, Non-Small Cell Lung Cancer, or Urothelial Carcinoma
|
Phase 2 | |
Active, not recruiting |
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Study Comparing TIL to Standard Ipilimumab in Patients With Metastatic Melanoma
|
Phase 3 | |
Active, not recruiting |
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Study of Lifileucel (LN-144), Autologous Tumor Infiltrating Lymphocytes, in the Treatment of Patients With Metastatic Melanoma
|
Phase 2 | |
Terminated |
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A Trial of Intratumoral Injections of SD-101 in Combination With Pembrolizumab in Patients With Metastatic Melanoma or Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
|
Phase 1/Phase 2 | |
Completed |
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A Translational Systems Medicine Approach to Provide Predictive Capacity for Therapy Response in Advanced or Metastatic Malignant Melanoma
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Withdrawn |
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Phase 1/Phase 2 | |
Withdrawn |
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Phase 2 | |
Terminated |
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Phase 2 | |
Completed |
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Phase 2 | |
Completed |
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Phase 2 | |
Terminated |
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Phase 1 | |
Recruiting |
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Phase 4 |