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FLOR3 Gene Polymorphism in Predicting Outcomes of Tyrosine Kinase Inhibitor（TKI）Stopping in Chronic Myeloid Leukemia — NTU-CML-001  

CML Clinical Trial

Official title:
A Multicenter Prospective Cohort Study of FLOR3 Gene Polymorphism in Predicting Outcomes of TKI-stopping in Chronic Myeloid Leukemia

Clinical Trial Summary

For patients with chronic myeloid leukemia in chronic phase (CML-CP) who have achieved a stable deep molecular response (DMR) using BCR-ABL1 tyrosine kinase inhibitors (TKIs), treatment-free remission (TFR) following TKI cessation is an emerging goal. However, about half of the patients relapsed after TKI discontinuation. There is no definite examinations to predict the outcome of TKI discontinuation. Investigators aim to study the relationship between FLOR3 SNP rs139130389 and the outcome of TKI discontinuation.

Clinical Trial Description

Investigators aim to detect FOLR3 SNP rs139130389, and establish its correlation with patients' treatment response, remission time, TKI resistance and the outcome of TKI stopping. ;

Study Design

Related Conditions & MeSH terms

  • CML
  • Folate
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Clinical Trial Details
NCT number NCT05152537
Study type Observational
Source Affiliated Hospital of Nantong University
Contact Hong Liu, Doctorate
Phone +8613951300660
Email hongliu63@126.com
Status Recruiting
Phase
Start date January 1, 2021
Completion date December 2023
View Details
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