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Clinical Trial Summary

A Global Multicenter, Open Label, Randomized, Phase 3 Registrational Study of Olverembatinib (HQP1351) in Patients with Chronic Phase Chronic Myeloid Leukemia (POLARIS-2)


Clinical Trial Description

This is a global, multi-center, open-label randomized and registrational phase 3 study of olverembatinib: Part A is a randomized controlled part that is designed to compare the efficacy and safety of olverembatinib (investigational arm) versus bosutinib (control arm) in patients with CML-CP, previously treated with at least two tyrosine kinase inhibitors (TKIs). Part B is to evaluate the efficacy and safety of olverembatinib in the CML- CP patients with T315I mutation. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06423911
Study type Interventional
Source Ascentage Pharma Group Inc.
Contact Ben Little
Phone 301-509-3222
Email ben.little@ascentage.com
Status Not yet recruiting
Phase Phase 3
Start date May 2024
Completion date February 2026

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