Clubfoot Clinical Trial
Official title:
The Pma Mouse and the Developmental Basis of Clubfoot: MRI Anatomical Modelling of Human ICTEV (Clubfoot)
The purpose of this study is to:
1. compare structural variations observed in the calf and foot of the clubfoot mouse
model(pma)with human clubfoot patients antenatally and postnatally;
2. identify features that might be used in future large scale studies to delineate a
subtype of human clubfoot associated with lack of response to standard 'Ponseti'
manipulation treatments.
Clubfoot is a medical condition of the foot known to doctors as "Congenital Talipes
Equinovarus (CTEV)", which affects at least 2 per 1000 Scottish births (ISD data). Affected
babies are born with one or both feet in an abnormal position. Treatment with plaster casts,
and occasionally with surgery, is necessary to get the foot into a normal position.
We know from our animal and clinical studies and published work that the normal processes of
development of the foot continue through pregnancy and postnatally. Clubfoot has never been
studied by MRI antenatally in humans, and examination of the foot before birth may offer
aetiological clues, not apparent from a single postnatal scan. Additionally, robust
information that will help to understand which features of clubfoot in utero predict a truly
affected fetus could be very useful for the clinical care of those suspected to be affected
at a 20 week scan. This study will provide preliminary data to determine whether the
usefulness of MRI in this context should be explored in future studies.
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Observational Model: Case Control, Time Perspective: Cross-Sectional
Status | Clinical Trial | Phase | |
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Withdrawn |
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Comparison of Ponseti Method Versus Older Treatments in Talipes Equinovarus Through Gait Analysis and Clinical Results
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Completed |
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Pedobarographic Assessments of Clubfoot Treated Patients
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Video Documented PBS-Score in Children With Clubfoot
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Recruiting |
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Therapeutic Recommendations Based on Clinical History and Video Documented PBS-Score
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Predictive Value of the PBS-score in Children With Clubfoot
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Completed |
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Gait Analysis in Ponseti Clubfoot
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N/A | |
Completed |
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Outcomes of Compliance With Brace Wear in Clubfoot
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N/A | |
Withdrawn |
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Economic Evaluation of Clubfoot Treatment: One Centre's Experience
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Completed |
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Polyaxial Brace Fixing for the Treatment of Congenital Clubfoot
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N/A | |
Not yet recruiting |
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Sucrose Analgesia in Infants Undergoing Casting for Club Foot
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N/A | |
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Using Botox to Treat Patients With Idiopathic Clubfoot
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Clonidine for Tourniquet-related Pain in Children
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Phase 4 | |
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N/A | |
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Comparison Study of LMX4 Cream Versus J-Tip Needle-Free Injection System With Lidocaine for In-Office PAT for Clubfoot
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Phase 4 | |
Not yet recruiting |
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CGH Array in Bilateral Clubfoot
|
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Completed |
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A Randomized Controlled Trial of Three Non-pharmacologic Analgesic Techniques for Casting of Clubfoot Infants
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N/A | |
Completed |
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Clubfoot DNA Repository
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N/A | |
Completed |
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Functional Assessment in Children With Clubfoot
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Active, not recruiting |
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Pronostic Factors of Long Term Outcome in Patients With Clubfoot Treated by the Ponseti Method
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Completed |
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Gait Analysis in Children With Clubfoot Treated With Tibialis Anterior Tendon Transfer
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