Genetic Linkage Study of Idiopathic Talipes Equinovarus (ITEV) (Clubfoot)

Clubfoot Clinical Trial

Official title:

Genetic Linkage Study of Idiopathic Talipes Equinovarus (ITEV) (Clubfoot)

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00474344
• Other study ID #: H04-70319
• Status: Completed
• Start date: August 2004
• Est. completion date: August 2013

Study information

• Verified date: May 2017
• Source: University of British Columbia
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The goal of this study is to identify and characterize the genetic loci causing idiopathic talipes equinovarus (clubfoot).

The hypothesis is that a few genes account for a substantial fraction of ITEV and that these genes can be identified in defined populations. Towards this goal, in preliminary studies, Dr. Hecht's group has identified two genes, NAT2 and CASP10, which demonstrate evidence for linkage and association to ITEV.

Description:

Blood Collection: For this study, the investigators need to obtain blood samples from members of families in which clubfoot has occurred; more specifically, blood samples from the affected child and both parents. DNA will be extracted from blood samples. The DNA will then be tested to look for genetic factors that cause clubfoot.

Study Questionnaires: As well as the blood samples, the investigators have a short questionnaire for the mother of the child with clubfoot to complete.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 370
• Est. completion date: August 2013
• Est. primary completion date: December 2010
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• One family member, usually child, must have clubfoot

Related Conditions & MeSH terms

• Clubfoot
• Equinus Deformity
• Foot Deformities

Locations

Country	Name	City	State
Canada	BC Children's Hospital	Vancouver	British Columbia
United States	University of Texas	Houston	Texas

Sponsors (3)

Lead Sponsor	Collaborator
University of British Columbia	National Institutes of Health (NIH), Shriners Hospitals for Children

Countries where clinical trial is conducted

United States,  Canada,