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Clostridium Infection clinical trials

View clinical trials related to Clostridium Infection.

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NCT ID: NCT04874623 Completed - Clinical trials for Clostridium Infection

Monoclonal Antibodies in Clostridium Difficile Infection

IgAClostridium
Start date: November 29, 2021
Phase: N/A
Study type: Interventional

Immunoglobulin A (IgA), the major mucosal antibody, plays a key role in maintaining diversity of the intestinal microbiota and eliminating intestinal pathogens. Dysbiosis is an important risk factor for Clostridium difficile infection, which is the leading cause of nosocomial diarrhea in industrialized countries. This study aims to develop IgA monoclonal antibodies targeting C. difficile surface proteins.

NCT ID: NCT00130221 Completed - Sepsis Clinical Trials

Skin Cleansing With Chlorhexidine to Decrease Hospital Acquired Infections

Start date: June 2005
Phase: Phase 1
Study type: Interventional

Patients in the intensive care unit are at risk for many infections because the severity of illness and the procedures necessary to care for them. This study is designed to look at a change in bathing procedure as a method to reduce infections. Currently, patients at John H. Stroger Hospital are cleansed with soap and water. However, preliminary data from a previous study at Rush University Medical Center showed that a chlorhexidine (CHG)-impregnated cloth (2% CHG Antiseptic Cloth system, Sage Products, Inc.) decreased skin bacteria and may lessen bacteria in the blood stream. The 2% CHG Antiseptic Cloth system is a non-irritating, no-rinse, cleansing and moisturizing product that contains 2% chlorhexidine gluconate. The goal of this proposed study is to further evaluate the effectiveness of the 2% CHG Antiseptic Cloth system compared with soap and water in cleansing the skin and preventing bacteria from entering the bloodstream.