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Clostridium Difficile Colitis clinical trials

View clinical trials related to Clostridium Difficile Colitis.

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NCT ID: NCT02127398 Recruiting - Clinical trials for Clostridium Difficile Colitis

Stool Transplants to Treat Refractory Clostridium Difficile Colitis

Start date: April 2016
Phase: Phase 2
Study type: Interventional

It has been shown that restoration of the normal makeup of the bowel bacterial population is the most effective way to treat recurrent colitis due to Clostridium difficile. Restoration of the normal bowel bacterial population is best done by transplanting stool from a healthy donor. The investigators wish to transplant stool from healthy donors to treat recurrent C. difficile colitis by incorporating the stool into capsules that are administered by the oral route.

NCT ID: NCT01630096 Recruiting - Clinical trials for Clostridium Difficile Colitis

Clostridial Infection and Oral Lavage -Improving Treatment Before Illness Becomes Severe

COLITIS
Start date: June 2012
Phase: Phase 4
Study type: Interventional

Once the lab test is positive for c. diff, the investigators will order the patient to have PEG 3350 solution, one 8oz glass every ten minutes until 6 liters are gone, but if still not clear 2 more liters may be ordered. At enrollment, the treatment arm will have an order for 500 cc Normal saline to be given I.V. The patient will continue with antibiotic treatment as well. The investigators will plan to check c. diff tests daily to see when they become negative. The investigators will perform chart audit/review to track mortality, the length of stay, ICU days, surgical intervention, and APACHE scores (assessment of disease severity). Chart audit will be used to collect data on their diet and how they feel using a visual analog scale (collected by nursing staff daily as a standard procedure; see attached pain scale). Using chart audit, the investigators will record whether the patient is immunocompromised or not.