Review and Assessment of Network Meta-analyses for Knowledge Uptake Study

Clinical Decision-making Clinical Trial

— RANK  

Official title:

Review and Assessment of Network Meta-analyses for Knowledge Uptake (RANK) Study

Clinical Trial Details — Status: Withdrawn

Administrative data

• NCT number: NCT03283592
• Other study ID #: 17-0107
• Status: Withdrawn
• Phase: N/A
• Start date: July 2019
• Est. completion date: January 2021

Study information

• Verified date: April 2019
• Source: St. Michael's Hospital, Toronto
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This randomized controlled trial will assess the interpretability of the rank-heat plot for presenting the results of network meta-analysis in comparison to SUCRA (surface under the cumulative ranking) plots which are suggested to present one of the best ranking statistics.

Description:

Clinicians are responsible for making decisions to improve health outcomes. When available, clinicians should use the results of a knowledge synthesis, such as systematic reviews and meta-analyses, to inform decision-making. Pairwise meta-analyses are limited, however, by the availability of RCTs that directly compare interventions. This is troublesome for knowledge users who require results from comparisons of multiple interventions to inform decision-making. To address this concern, the use of network meta-analyses (NMAs) is increasing in healthcare the literature. NMAs are a useful tool because they can summarize results from numerous studies and interventions. It is unclear how NMA results should be presented to increase the likelihood of clinicians understanding and using the results to improve health outcomes. Thus, a randomized controlled trial of NMA plots will be conducted. Participants will be randomized to either the rank-heat plot (intervention) or SUCRA plots (control) that present the same NMA results of a study that explored the effectiveness of quality improvement interventions for falls prevention. Outcomes will be ascertained via an online survey. The RCT will take place in an online environment and will require each participant to partake in a single session. This study will help guide best practices for the presentation of reviews to improve the uptake and use of NMA.

Recruitment information / eligibility

• Status: Withdrawn
• Enrollment: 0
• Est. completion date: January 2021
• Est. primary completion date: January 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Clinicians must be accredited to practice in Canada and working (full- or part-time) as a family physician or general internist.

Exclusion Criteria:

• Unable to read and understand English;

• No access to the internet;

• Read, co-authored or peer-reviewed the study: "Quality Improvement strategies to Prevent Falls in the Elderly: A systematic review and network meta-analysis" (manuscript in preparation).

Related Conditions & MeSH terms

• Clinical Decision-making

Intervention

Other:
• Rank-Heat Plot
provides a visual presentation of treatment hierarchy across multiple outcomes
• SUCRA Plot
provides a visual presentation of treatment ranking for a single outcome.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
St. Michael's Hospital, Toronto

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Proportion of participants who appropriately define the clinical "bottom line." Participants' answers will be independently evaluated by two investigators for agreement with an expert panel's recommendation.		during experiment via single session, <1 hour survey
Secondary	Proportion of participants who accurately apply the evidence to the provided clinical scenario.		during experiment via single session, <1 hour survey
Secondary	Completeness of survey data evaluated by two independent investigators		Immediate post-experiment
Secondary	Time taken to complete survey		Immediate post-experiment