Cleft Lip Post-surgical Scar Clinical Trial
Official title:
Assessment of Fractional CO2 Laser in Treatment of Post-surgical Scarring of Cleft Lip
This is a prospective comparative study on 120 patients divided to three groups. Group A: 40
patients laser will be applied 3 weeks post-surgical. Group B: 40 patients laser will be
applied 3 months post surgical. Group C: 40 patients as a control not treated with laser from
2017 to 2020 which will be conducted on patients with post-surgical cleft lip repair scaring.
All patients will have 5-7 sessions with 4 weeks interval.
Photographic documentation and evaluation of the scar will occur every 4 weeks.
The carbon dioxide laser (CO2 Laser) was one of the earliest gas lasers to be developed. It
was invented by Kumar Patel of Bell Labs in 1964.
CO2 laser is the highest power continuous wave lasers that are currently available which
produces a beam of infrared light with the principal wavelength bands centering on 9.4 and
10.6 micrometers. Patel, C. K. N. (1964).
When CO2 beam of light is selectively applied to the skin, it heats and vaporizes various
layers of skin, instantly treating damaged skin and wrinkles while smoothing out the surface
of the skin.
The skin remodeling occurs with new skin and collagen growth. The healing typically involves
an open surface which takes weeks to heal and typically results in loss of the baseline
pigmentation leading to variable lightening of skin. Dover, J. S. (2012) Fractional CO2 laser
resurfacing is a revolutionary delivery system that provides dramatic skin improvement
without surgery. Matrix combines the benefits of CO2 laser by using micro laser columns
"points of light" to treat the epidermis and dermal layers of your skin.
Bernstein et al, (1997) Cleft lip is a form of lip malformation that occurs very early in
pregnancy, the incidence of cleft lip in the population is approximately 0.5-2 in 1000 live
births. Male children are affected more often than female children.
Michalski AM et al, (2015). Because each cleft is unique, definitive repair of the cleft lip
should be individualized as Mirault, Le Mesurier, Tennison, and Millard.
Stal S et al, (2009)
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