Dental Age Estimation by Different Methods in Patients With Cleft Lip and Palate

Cleft Lip and Palate Clinical Trial

Official title:

Evaluation of Dental Age of Children With Cleft Lip and Palate Using Willems Method, Cameriere European Formula, and London Atlas

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05573295
• Other study ID #: 2021/68
• Status: Recruiting
• Start date: March 1, 2022
• Est. completion date: August 15, 2024

Study information

• Verified date: March 2024
• Source: Istanbul University
• Contact: Yelda Kasimoglu Eldem, Assoc. Prof.
• Phone: 00905336233978
• Email: yelda.kasimoglu[@]istanbul.edu.tr
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The aim of this study is to investigate whether there is a significant difference in dental age between children with CLP and healthy controls using the Willems method, Cameriere European formula and London Atlas. It is aimed to create a new formula if there is a significant difference in dental age between children with CLP and healthy controls.

Description:

Dental age is widely evaluated by pedodontists, forensic dentists and orthodontists. While a delay in tooth development may be associated with growth retardation and learning difficulties, dental age determination can also be used for forensic age determination for children whose birth information is uncertain. A clear assessment of maturation in children with continued growth is important in establishing a dental treatment plan.

There are two basic approaches to dental age determination in children:

evaluation of eruption of teeth in the oral cavity, evaluation of the development and mineralization of crowns and roots on dental radiographs.

In many methods, the developmental stages of different numbers of permanent teeth are used.

The most commonly used method for determining dental age in children; is the Demirjian method that evaluates the development of seven left permanent mandibular teeth in eight stages (from A to H). Willems et al. In 2001, they modified the Demirjian method by conducting a study on the fact that it showed higher age determination in the Belgian Caucasian population. The adapted method was named the Willems method. It is stated that one of the advantages of this method is that it is a relatively simple system for determining tooth age.

One of the most widely used methods of dental age determination recently is the European formula of Cameriere et al., which is calculated based on open apex. It has been reported that this method has been tested on different population groups, and the results are accurate and reliable.

An atlas method was proposed by a group of London researchers in 2010. The Atlas shows all the teeth array images of certain age groups as a schematic series. Age determination is made by deciding which reference image matches the individual's panoramic radiography image more.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 240
• Est. completion date: August 15, 2024
• Est. primary completion date: July 15, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 5 Years to 14 Years

Eligibility

Inclusion Criteria:

• 5-14 years old

• Healthy children

• Children with CLP

• Patients without missing left mandibular permanent teeth on panoramic radiography

Exclusion Criteria:

• Children younger than 5 years old and older than 14 years (children that cannot be assessed by the Willems and Cameriere method)

• Poor quality panoramic radiography

• Patients who have received orthodontic treatment

• Patients who received restorative or endodontic treatment

Related Conditions & MeSH terms

• Cleft Lip
• Cleft Lip and Palate

Intervention

Other:
• Diagnostic Test: Willems method
Willems method measures the developmental stages of the seven left permanent mandibular teeth and is frequently used for dental age estimation. The score of each stage is allocated, and the sum of the scores provides an evaluation of the subject's dental maturity.
• Diagnostic Test: Cameriere method
Cameriere et al. designed a quantitative approach through a formula based on sex and the ratio between length and apex opening measurements of each lower left tooth.
• Diagnostic Test: London Atlas method
The London Atlas requires the user to assess the tooth development and eruption and then match it to one of the 31 pictures of age categories.

Locations

Country	Name	City	State
Turkey	Istanbul University, Faculty of Dentistry	Istanbul

Sponsors (1)

Lead Sponsor	Collaborator
Istanbul University

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Correlation coefficient of Willems method	Dental age of children with Cleft Lip and Palate and healthy controls assessed by the correlation coefficient	day 1
Primary	Correlation coefficient of London Atlas method.	Dental age of children with Cleft Lip and Palate and healthy controls assessed by the correlation coefficient.	day 1
Primary	Correlation coefficient of Cameriere European formula.	Dental age of children with Cleft Lip and Palate and healthy controls assessed by the correlation coefficient.	day 1
Secondary	Dental age estimation in children with Cleft Lip and Palate	Dental age estimation in Turkish children	day 1