Cleft Lip and Palate Clinical Trial
Official title:
Use of Mesenchymal Stem Cells for Alveolar Bone Tissue Engineering for Cleft Lip and Palate Patients
The aim of this study is to perform the bone tissue engineering to reconstruct the alveolar bone defect in cleft lip and palate patients using mesenchymal stem cells from deciduous dental pulp associated with a collagen and hydroxyapatite biomaterial (Geistlich Bio-Oss®) through prospective qualitative and quantitative analysis of bone neoformation.
The reconstruction of the craniofacial skeleton in development between 2 and 10 years old,
remains a major challenge for reconstructive plastic surgery. Local autogenous bone is
practically unavailable, the distant bone graft has significant morbidity and use of
alloplastic materials is incompatible with the growing facial skeleton. With the advent of
bioengineered tissue, however, osteogenesis induced by the use of mesenchymal stem cells
associated with biomaterials has become a potential solution to the shortage bone-related
morbidity and donor bone in the region in pediatric patients.
The association of mesenchymal stem cells to biomaterials has provided new bone formation and
a significant reduction of morbidity, for rehabilitation of the alveolar bone in patients
with cleft lip palate.
To perform the rehabilitation of alveolar bone cleft, other donor regions of bone (iliac
crest, ribs, skull) suffer morbidity for obtaining bone to be used in alveolar bone grafting.
In order to eliminate the morbidity at the bone donor region for these patients and reduce
costs of patient permanence in the operating room the aim of this study is to perform the
bone tissue engineering to reconstruct the alveolar bone defect in cleft lip and palate
patients using mesenchymal stem cells from deciduous dental pulp associated with a collagen
and hydroxyapatite biomaterial (Geistlich Bio-Oss®) through prospective qualitative and
quantitative analysis of bone neoformation.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Enrolling by invitation |
NCT05876169 -
How Does Orthognathic Surgery Affect Jaw and Neck Motor Function?
|
N/A | |
| Recruiting |
NCT04455035 -
DynaCleft® Effects on Soft Tissues and on Quality of Life for Incomplete Unilateral Cleft Lip Infants
|
N/A | |
| Not yet recruiting |
NCT05031039 -
Skeletal and Dental Maturational Stages in a Sample of Egyptian Subjects With Cleft Lip and Palate Deformity
|
||
| Recruiting |
NCT03839290 -
Development of the Palate in Bilateral Orofacial Cleft Newborns One Year After Early Neonatal Cheiloplasty
|
||
| Recruiting |
NCT04771156 -
Ketorolac in Palatoplasty
|
Phase 4 | |
| Completed |
NCT04725370 -
Characterization of Cleft Lip and Palate Conditions in Guatemala
|
||
| Enrolling by invitation |
NCT02702869 -
Allied Cleft & Craniofacial Quality-Improvement and Research Network (ACCQUIREnet)
|
||
| Active, not recruiting |
NCT05971914 -
Alveolar Cleft Hard- and Soft Tissue Reconstruction With an Autogenous Tooth Derived Particulate Graft
|
N/A | |
| Completed |
NCT03708406 -
Otologic and Rhinologic Outcomes in Children With Clef Palate
|
||
| Recruiting |
NCT06105099 -
Effect of Performance-specific Cleft Speech Intervention and Long-term Learning in Children With a Cleft Palate
|
N/A | |
| Completed |
NCT06075069 -
Evaluation of the Effect of Prosthetic Management for Congenital Cleft Lip and Palate Infants on the Middle Ear Function
|
N/A | |
| Completed |
NCT04384276 -
Weigh Easy: Simplifying Home Weight Monitoring for Infants
|
N/A | |
| Recruiting |
NCT04619030 -
Augmented Reality (AR): The Future of "Patient Information Leaflets
|
N/A | |
| Recruiting |
NCT03065686 -
Identification of Genetic Factors Implicated in Orofacial Cleft Using Whole Exome Sequencing
|
N/A | |
| Completed |
NCT02845193 -
Effect of Novel Nasoalveolar Molding Techniques on Parents' Satisfaction and Short Term Treatment Outcomes in Unilateral Cleft Lip and Palate Infants: A Randomized Controlled Trial
|
N/A | |
| Completed |
NCT03308266 -
Electromyographic Analysis of the Masticatory Muscles in Cleft Lip and Palate Children With Temporomandibular Disorders
|
N/A | |
| Not yet recruiting |
NCT06411444 -
Effect of Different Nasal Stent Designs With Nasoalveolar Molding Appliance
|
N/A | |
| Not yet recruiting |
NCT06292234 -
Patient Specific Implant Versus Miniplates for Advancement of Hypoplastic Maxilla
|
N/A | |
| Recruiting |
NCT05081258 -
Influence of Presurgical Orthodontic Molding on the Growth of Newborns With Unilateral Cleft Lip Palate
|
N/A | |
| Not yet recruiting |
NCT04791813 -
Assessment of Maxillary Arch Depth and Width in a Group of Surgically Repaired Unilateral Cleft Lip and Palate Children Versus Normal Children .
|