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Lactate Increase in Peripheral Artery Disease — STELLA  

Peripheral Artery Disease Clinical Trial

Official title:
Study of Transcutaneous Exercise Oxymetry, reLationship to LActates Increase in Claudication

Clinical Trial Summary

To our knowledge, the measurement of the transcutaneous oxygen pressure during walking is the only continuous method that estimates the importance of ischemia, bilaterally and segment of limb by segment of limb. The determination of the lactates concentration, with micro method from earlobe sampling, is very widely validated in physiology and exercise physiopathology; and it is widely used, by laboratories, for exercise investigation in athletes. We use it in routine to evaluate the presence of functional limitation during tcpO2 tests on a treadmill. The present study hypothesises a significant relationship between lactatemia variation (difference between lactatemia after 3 minutes of recovery from walking and the value at rest) and tcpO2 "decrease from rest of oxygen pressure (DROP) values for patients with peripheral artery disease (PAD).

Clinical Trial Description

Lactates sample (100 microliter) will be collected at rest Ankle brachial index is measured at rest transcutaneous oxygen pressure is measured at the chest, calves and buttocks and results will be expressed as the minimal value of the DROP index (Limb changes minus chest changes) Patients walk on treadmill (2MPH 10% slope) until exertional limb pain. Lactates sample (100 microliter) will be collected at minute 3 of recovery from walking Correlation of lactate increase to the sum of DROP values wil be studied ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03266861
Study type Observational
Source University Hospital, Angers
Contact
Status Completed
Phase
Start date October 3, 2017
Completion date October 10, 2020
View Details
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