Study of the Relationship Between Blood Groups,RH and Skeletal Malocclusion : a Cross Sectional Study

Class II Malocclusion Clinical Trial

Official title:

Study of the Relationship Between Blood Groups,RH and Skeletal Malocclusion in a Group of Egyptian Population: a Cross Sectional Study

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT03085082
• Other study ID #: skeletal_malocclusion_ABO
• Status: Not yet recruiting
• Phase: N/A
• First received: March 15, 2017
• Last updated: March 20, 2017
• Start date: April 1, 2017
• Est. completion date: December 31, 2017

Study information

• Verified date: March 2017
• Source: Cairo University
• Contact: Noor Elsebai
• Phone: 01023415842
• Email: noorelsebai[@]gmail.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

the study is searching if there is a relationship between the blood groups and RH and the skeletal malocclusion using the skeletal class I as a control group

Description:

The study will be conducted on the patients seeking medical care in the orthodontic department Cairo University, for six months all patients with class II and class III malocclusion will be recruited based on Wits appraisal measured from the cephalometric X-ray taken routinely during orthodontic examination. Then a group of class I arch length discrepancy patients will be used as control. A blood sample will be withdrawn and taken to the Cairo university laboratory to analyze the blood group and RH .a statistical analysis will be performed to detect a relationship between skeletal malocclusion and the blood groups as compared to the control

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 300
• Est. completion date: December 31, 2017
• Est. primary completion date: September 1, 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

skeletal class I,II and III patients non syndromic patients above the age of 18 no previous surgical intervention for correction of skeletal malocclusion

Exclusion Criteria:

• syndromic patients

• cleft patients

• patients with previous surgery to correct skeletal malocclusion

Related Conditions & MeSH terms

• Class II Malocclusion
• Class III Malocclusion
• Malocclusion
• Malocclusion, Angle Class II
• Malocclusion, Angle Class III
• Prognathism

Intervention

Diagnostic Test:
• blood type test
a blood sample will be withdrawn from the subjects tested by anti A anti B and anti D antigens to detect the individuals blood group and RH. then statistical analysis to detect presence of a relationship between skeletal types of malocclusion and ABO blood groups

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Cairo University

References & Publications (4)

Flannery, P. M. (1969). Loyola eCommons The Abo Human Blood Groups and Skeletal Class IIi Malocclusions.

Gheisari R, Ghoreishian M, Movahedian B, Roozbehi A. The association between blood groups and maxillofacial deformities. Indian J Plast Surg. 2008 Jul;41(2):138-40. doi: 10.4103/0970-0358.44921. — View Citation

Schnibben, C. L. (1968). Loyola eCommons A Study of the Relationships of the ABO Human Blood Groups , the Rh Factor and Hereditary Malocclusions of the Skeletal Type , Class II , Division 1.

Science, D. (2015). International Journal of Pharma and Bio Sciences ISSN CRANIOFACIAL MORPHOLOGY WITH GENETIC INFLUENCE OF ABO BLOOD, 6(4), 412±418.

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	relationship between blood group and skeletal malocclusion	If skeletal malocclusion subjects were found to have a high percentage of a certain blood type or RH when compared to the control group it will be reported that there is a relationship between blood group and skeletal malocclusion. If percentages of blood groups are approximately the same in the malocclusion subjects and the control then the investigator will report that there is no relationship between blood groups and skeletal malocclusion	the recruitment will be for six months