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Cirrhotic Cardiomyopathy clinical trials

View clinical trials related to Cirrhotic Cardiomyopathy.

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NCT ID: NCT01676285 Completed - Cirrhosis Clinical Trials

Metoprolol Succinate in Cardiac Remodeling Related to Cirrhosis

CARE Cirrhosis
Start date: January 2012
Phase: Phase 3
Study type: Interventional

Cirrhotic cardiomyopathy is defined as a chronic cardiac dysfunction in patients with cirrhosis. It is suspected that this specific cardiac dysfunction contributes to the onset of complications in liver disease. The purpose of this prospective, randomized trial is to determine whether metoprolol succinate can revert cardiac dysfunction secondary to cirrhosis (cirrhotic cardiomyopathy), and prevent complications (renal dysfunction, mortality). A total of 100 patients with cirrhotic cardiomyopathy will be randomized (Group R) to receive metoprolol succinate or placebo; other 25 patients without cirrhotic cardiomyopathy (Group F) will only be followed up without medication. All patients will be evaluated in the beginning and again after six months. The assessment protocol includes clinical evaluation, electrocardiogram, echocardiogram, laboratory analysis and life quality questionaire. The end points will be cardiac remodeling, electrophysiologic changes, sympathetic activity, laboratory issue changes, renal function, quality of life, and mortality.

NCT ID: NCT00250315 Completed - Cirrhosis Clinical Trials

DOCICAR: Cardiac Dysfunction in Cirrhosis

Start date: November 2005
Phase: Phase 3
Study type: Observational

Patients with cirrhosis have a altered cardiac response to stress. This study evaluate the cardiac response by MRI during dobutamine stress. Hypothesis: impared increase in cardiac output, cardiac index, ejection fraction.