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NCT04199910 Clinical Trial

4beta-hydroxycholesterol in Cirrhosis

Cirrhosis, Liver Clinical Trial

Official title:
4beta-hydroksikolesteroli Maksakirroosissa

Clinical Trial Details — Status: Suspended

Administrative data
NCT number NCT04199910
Other study ID # 4bHC kirroosissa
Secondary ID
Status Suspended
Phase
First received
Last updated
Start date December 1, 2019
Est. completion date December 31, 2024

Study information
Verified date May 2024
Source University of Oulu
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The aim is to evaluate the levels of oxysterols and especially 4beta-hydroxycholesterol in patients with liver cirrhosis. Three cirrhosis cohorts are recruited: patients treated with spironolactone, patients treated with rifaximin, patients without spironolactone or rifaximin. Also three other control cohorts are recruited: patients with pneumonia, patients with Crohn's disease, patients with ulcerative colitis. The effect of the cirrhosis and its medications spironolactone and rifaximin are compared to control groups.

Recruitment information / eligibility
Status Suspended
Enrollment 120
Est. completion date December 31, 2024
Est. primary completion date December 31, 2024
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Patients with cirrhosis, pneumonia, Crohn's disease or colitis ulcerosa - Treated in the ward 42 of the Oulu University Hospital Exclusion Criteria: - None

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• There is no intervention, only research blood samples are collected
Research blood samples collected

Locations
Country Name City State
Finland Oulu University Hospital Oulu

Sponsors (1)
Lead Sponsor Collaborator
University of Oulu

Country where clinical trial is conducted

Finland, 

Outcome
Type Measure Description Time frame Safety issue
Primary Blood 4beta-hydroxycholesterol concentration Blood 4beta-hydroxycholesterol concentration At the time point of the blood collection - cross-sectional. One day.
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