Physiologic Effect of Topical Nitroglycerin on Microcirculation Capacity

Clinical Trial Summary

This is an open-label, single center, trial that will enroll up to 25 participants with circulatory shock after cardiac surgery. Participants will be administered a topical sublingual nitroglycerin solution and assessed for changes microcirculatory blood flow using incident dark field microscopy.

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT04357275` - The RIsk Stratification in COVID-19 Patients in the ICU Registry
Withdrawn	`NCT03483753` - Vasopressin or Norepinephrine in Vasoplegic Shock After Non-cardiac Surgery	Phase 2/Phase 3
Active, not recruiting	`NCT06376318` - Shock and Acute Conditions OutcOmes Platform
Recruiting	`NCT06265259` - Efficacy of the Use of Vasopressin as a Primary Vasoconstrictor in Critically Ill Patients	Phase 4

See also

Status

Clinical Trial

Phase

Active, not recruiting

NCT04357275 - The RIsk Stratification in COVID-19 Patients in the ICU Registry

Withdrawn

NCT03483753 - Vasopressin or Norepinephrine in Vasoplegic Shock After Non-cardiac Surgery

Phase 2/Phase 3

Active, not recruiting

NCT06376318 - Shock and Acute Conditions OutcOmes Platform

Recruiting

NCT06265259 - Efficacy of the Use of Vasopressin as a Primary Vasoconstrictor in Critically Ill Patients

Phase 4

Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.

Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.

Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

NCT number	NCT05102734
Study type	Observational
Source	University of Pennsylvania
Contact
Status	Completed
Phase
Start date	September 1, 2021
Completion date	March 1, 2022

Physiologic Effect of Topical Nitroglycerin on Microcirculation Capacity in Patients With Circulatory Shock.

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms