Clinical Trials Logo
  1. Home
  2. Circulatory Failure
  3. NCT03210818

Effects of Blood Flow of Venoarterial Extracorporeal Membrane Oxygenation Life Support on Microcirculation

Circulatory Failure Clinical Trial

Official title:
Effects of Adjustment of Blood Flow of Venoarterial Extracorporeal Membrane Oxygenation Life Support on Microcirculation

Clinical Trial Summary

Extra-corporeal membrane oxygenation (ECMO) life support system can provide both cardiac and respiratory support to patients with heart and respiratory failure. It can save time for these patients to regain organ function or to receive transplantation. Both the investigators' team and Ince et al. from the Netherland found that the microcirculatory dysfunction is more severe in ECMO non-survivors. The next step of research is to find out the key factors that affect microcirculation in ECMO patients. Because the blood flow supplied by the venoarterial ECMO (VA-ECMO) is directly related to macrocirculation, this study aims to investigate the effect of adjustment of VA-ECMO blood flow on microcirculation. The investigators hope that the results of this study can help the medical team to improve the quality of ECMO care.

Clinical Trial Description

After evaluation, explanation, and acquisition of agreement, the sublingual microcirculation will be examined within 24 h and at 48 h after placement of VA-ECMO. The VA-ECMO blood flow will be recorded, and the baseline microcirculation will be examined. After the ECMO technician adjusting the ECMO flow, sublingual microcirculation will be examined 2 minutes after each adjustment, and the change of ECMO blood flow will be recorded. When the ECMO team plans to weaning off the ECMO within 72 h, the sublingual microcirculation will be examined. The VA-ECMO blood flow will be reduced by ECMO technician, and sublingual microcirculation will be examined 2 minutes after each adjustment of the blood flow. The ECMO parameters, medications, and clinical data will be recorded, and the prognosis will be followed up on the 28th day. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03210818
Study type Observational
Source National Taiwan University Hospital
Contact
Status Completed
Phase
Start date November 5, 2017
Completion date April 30, 2019
View Details
See also
  Status Clinical Trial Phase
Completed NCT03622099 - Small Volume Fluid Challenge as a Predictor of Fluid Responsiveness in Patients With Circulatory Failure
Completed NCT02726776 - Suspension Syndrome N/A
Completed NCT02051894 - NeoAdapt 3: Novel Biomarkers in the Evaluation of Neonatal Circulatory Insufficiency in Babies Suffering From Hypoxic Ischemic Encephalopathy N/A
Completed NCT02248025 - Can Capillary Refill Time Variation During Passive Leg Raising Predict Fluid Responsiveness N/A
Completed NCT02083757 - Fluid Responsiveness Predicted by PtcO2 in Critically Ill Patients N/A
Completed NCT04538339 - Prediction of Arterial Lactate and Blood Gas Values Through the Analysis of Central Venous Blood
Completed NCT03917446 - Volume Responsiveness Assesment After Propofol.
Completed NCT04526249 - Evaluation of Efficacy of the Prototype RPC (Rapid Pulse Confirmation) Device in Detecting Return of Pulsatile Flow in Patients Preparing to Separate From CPB (Cardiopulmonary Bypass)
Recruiting NCT06285331 - the Impact of Manual or Mechanical Ways to Perform PLR on the Accuracy of Evaluation of Fluid Responsiveness N/A
Completed NCT03066362 - Respiratory Variations for Predicting Fluid Responsiveness N/A
Completed NCT03873675 - Parathyroid Hormone Kinetics During CRRT
Completed NCT03066375 - Respiratory Variations For Predicting Fluid Responsiveness 2 N/A
Recruiting NCT06442267 - Comparing Anticoagulation Strategies Using UFH, Argatroban and LMWH for ECMO Support Phase 4
Recruiting NCT04474249 - Follow-up of Critical COVID-19 Patients
Recruiting NCT04037644 - Volume Expansion With Albumin vs. Crystalloid and Expiratory Lung Impedance Phase 2/Phase 3
Completed NCT02505646 - Fluid Responsiveness Evaluation by AbdomiNal Compression in Kids Based on the STARLING Concept N/A
Completed NCT02051855 - NeoAdapt 2: An Observational Study Investigating Novel Biomarkers in the Evaluation and Treatment of Neonatal Circulatory Insufficiency N/A
Completed NCT01590511 - Echocardiographic Prediction of Fluid Responsiveness After a Mini-fluid Challenge in Non-ventilated Patients With Shock N/A
Terminated NCT02974790 - Diagnostic Performance of Echocardiography Performed by Emergency Physicians After a Basic Training
Completed NCT02992002 - Influence of Fluid Challenge on End-Expiratory Lung Impedance in Mechanically Ventilated Patients Monitored With Electrical Impedance Tomography