Influences of Phenylephrine, Dopamine and Ephedrine on Stroke Volume Variation and Pulse Pressure Variation

Circulation Clinical Trial

Official title:

Influences of Phenylephrine, Dopamine and Ephedrine on Stroke Volume Variation and Pulse Pressure Variation

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02201121
• Other study ID #: plaghran001
• Status: Completed
• Phase: N/A
• First received: July 22, 2014
• Last updated: July 24, 2014
• Start date: March 2014
• Est. completion date: June 2014

Study information

• Verified date: October 2013
• Source: Chinese PLA General Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: China: State Administration of Traditional Chinese Medicine of the People's Republic of China
• Study type: Interventional

Clinical Trial Summary

Although induced hypertension decreased SVV and PPV,the influences of stroke volume variation and pulse pressure variation caused by phenylephrine,dopamine and ephedrine were unknown.

Description:

Pulse pressure variation (PPV) and stroke volume variation (SVV) during mechanical ventilation have been shown to be effective parameters to predict preload responsiveness. Although induced hypertension decreases PPV and SVV, the influences of phenylephrine, dopamine and ephedrine on PPV and SVV are unknown.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 94
• Est. completion date: June 2014
• Est. primary completion date: June 2014
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• Their American Society of Anesthesiologists (ASA) physical status was 1 or 2

• Body mass index (BMI) ranged from 18 to 26

• None of the patients had known diabetes mellitus, hypertension, cardiovascular, pulmonary, endocrinological, neurological diseases, or diseases that influenced intravascular fluid volume or balance

• All patients had a preoperative fast for at least 8 h and routine atropine intramuscular injection

Exclusion Criteria:

• Persistent arrhythmias

• Intraoperative application of vasoactive drugs except phenylephrine, dopamine and ephedrine

Study Design

Intervention Model: Single Group Assignment, Masking: Single Blind (Subject)

Related Conditions & MeSH terms

• Calculated SAP
• Circulation
• Drug Dose

Intervention

Other:
• Influences of phenylephrine, dopamine and ephedrine on stroke volume variation and pulse pressure variation
This research mainly study the effect of clinical commonly used vasoconstrictor drugs on blood pressure of pressure

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Chinese PLA General Hospital

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	invasive arterial blood pressure as a Measure of Safety	if instability of circulation, stop the clinical trial	DAY 1	Yes