Circulating Tumor Cell Clinical Trial
Official title:
A Retrospective Study of Data Related to Circulating Tumor Cell Detection in Hepatocellular Carcinoma
Verified date | March 2022 |
Source | Tongji Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The investigators examined circulating tumor cells (CTC) in the perioperative peripheral blood of hundreds of HCC patients undergoing liver cancer surgery using CellSearch technology between 2013 and 2016. Although the investigators have done a preliminary study of the above data and published some results, the previous study was only a basic analysis. Now the investigators plan to carry out further in-depth analysis of these data, including hospitalization data, follow-up results, surgical tumors and blood specimens, and make full use of biostatistics, molecular biology, pathology and other related techniques to elucidate the association between the levels of CTC or CTC clusters and patients' disease during the perioperative period, and to explore the molecular basis of CTC production in hepatocellular carcinoma.
Status | Completed |
Enrollment | 458 |
Est. completion date | March 15, 2022 |
Est. primary completion date | June 30, 2016 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 80 Years |
Eligibility | Inclusion Criteria: - The pathological diagnosis was primary liver cancer. - Undergoing radical surgical treatment - No preoperative antitumor therapy was received - Between 18 and 80 years old Exclusion Criteria: - With distal metastasis - With other tumors - Perioperative death - Recurrence within one month after surgery - Lost contact before the first follow-up |
Country | Name | City | State |
---|---|---|---|
China | Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | Wuhan | Hubei |
Lead Sponsor | Collaborator |
---|---|
Tongji Hospital |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Data analysis of relationship between CTC and pathological indicators of hepatocellular carcinoma | The previous CTC detection data of 458 cases was collected. To compare the relationship between CTC level of perioperative peripheral blood and clinical indexes of HCC patients, the main statistical analysis were one-way ANOVA, Student's T test and Multivariable Cox regression. | 2022.03.15 |
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