Clinical Trials Logo
  1. Home
  2. Circadian Rhythm
  3. NCT02642640

Interaction of Melatonin and MTNR1B Genotype on Glucose Control - Study 1

Circadian Rhythm Clinical Trial

Official title:
Interaction of Melatonin and MTNR1B Genotype on Glucose Control - Study 1

Clinical Trial Summary

This project aims to test the impact of melatonin and MTNR1B variation on regulation glucose regulation in a highly controlled in-laboratory setting and ex vivo in pancreatic islets.

Clinical Trial Description

The investigators' recent GWAS discovery of MTNR1B as a novel type 2 diabetes gene has sparked great interest into the role of melatonin in glycemic control, for which the mechanism is largely unknown. This research will determine the effect of melatonin and MTNR1B on glycemic control under highly-controlled, in-laboratory protocols while manipulating circulating melatonin concentrations (both up and down) and assessing glycemic control by frequently-sampled intravenous glucose tolerance tests, as well as in ex vivo human pancreatic islets. This research will provide mechanistic insights into the metabolic effects of melatonin and the MTNR1B risk variant and may help in evidence-based approaches and personalized recommendations to improve glycemic control in night shift workers and late-night eaters. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02642640
Study type Interventional
Source Brigham and Women's Hospital
Contact
Status Completed
Phase N/A
Start date November 2016
Completion date March 24, 2022
View Details
See also
  Status Clinical Trial Phase
Completed NCT04934436 - The Effect of Nursing Care on Circadian Rhythm N/A
Recruiting NCT06401837 - Acupressure Therapy on Post-stroke Fatigue, Depression, and Sleep Disturbances in Ischemic Stroke Patients N/A
Recruiting NCT05093088 - Effect of Circadian Rhythm on Brain NAD Measured by Phosphorus Magnetic Resonance Spectroscopy at 7 Tesla
Suspended NCT05107947 - Light in Frail Elderly - the Effect of a Dynamic Light for Sleep and Circadian Rhythm N/A
Completed NCT00607204 - Examining the Biological Factors That Affect Sleep Duration N/A
Completed NCT02604875 - The Circadian Rhythm of Copeptin N/A
Completed NCT00707226 - Circadian Variations in Ocular Blood Flow in Glaucomatous and Normal Eyes N/A
Recruiting NCT05115682 - Circadian Rhythm and Metabolic Effects of Exercise N/A
Completed NCT03366025 - Progesterone Variation on the Final Day of Oocyte Maturation.
Completed NCT05409339 - Influence of Caffeine Consumption on the Human Circadian System N/A
Completed NCT04448197 - Insomnia Treated by Traditional Chinese Medicine and Its Circadian Rhythm
Completed NCT00945230 - Actigraphic Measurement of a Neurosurgical Procedure N/A
Active, not recruiting NCT02384148 - Study of Circadian Clock Properties in Healthy Subjects, Obese and Type 2 Diabetic Patients. N/A
Completed NCT00456222 - Impact of Sleep Disruption on the Menstrual Cycle N/A
Recruiting NCT05795881 - Effect of Continuous Versus Cyclic Daytime Enteral Nutrition on Circadian Rhythms in Critical Illness N/A
Recruiting NCT04921215 - Teen Sleep and Light Study N/A
Enrolling by invitation NCT05656768 - Sleep and Circadian Contributions to Nighttime Blood Pressure N/A
Completed NCT01900639 - Aspirin AM or PM: Effect on Circadian Rhythm of Platelet Reactivity Phase 4
Completed NCT04129918 - Effects of Light and Sound Modification on Sleep Quality and Circadian Rhythm in the MICU Patients N/A
Completed NCT05452577 - Treatment of Chronic Insomnia According to Yin Yang Theory and Its Correlation With Circadian Rhythm N/A