Ganglion Cell Thickness in Enuresis Nocturna

Circadian Rhythm Disorders Clinical Trial

Official title:

Is Ganglion Cell Thickness the Main Problem in Enuresis Nocturna?

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05126732
• Other study ID #: 341/321
• Status: Recruiting
• Start date: January 2022
• Est. completion date: July 2022

Study information

• Verified date: November 2021
• Source: Izmir Bakircay University
• Contact: Yasar ISSI
• Phone: 00905321704131
• Email: yasarissi[@]yahoo.com
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

The precise role of the intrinsic circadian regulatory mechanism behind the pathogenesis of enuresis is not fully understood, but in theory, circadian rhythm irregularity may be the primary pathogenic mechanism not only for urinary outflow mechanisms but also for nocturnal bladder function. The proximity between SCN centers that control AVP release, sleep/arousal, voiding, and baroreregulation may provide the basis for circadian rhythm disturbance in one or more of these biological functions. Ganglion cells containing melanopsin pigment in the retina transmit the information they receive from the outside world about the light-dark state to the SCN via the retinohypothalamic pathway. Peripapillary retinal nerve fiber layer (RNFL) thickness, optic nerve head and macula are examined most frequently for the diagnosis of glaucoma and the detection of progression with optical coherence tomography (OCT). If differences in ganglion cell thickness can be detected using OCT in these children, a new avenue in Enuresis Nocturna may be opened.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 50
• Est. completion date: July 2022
• Est. primary completion date: April 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 5 Years to 18 Years

Eligibility

Inclusion Criteria:

• be between the ages of 5-18

• have enuresis

Exclusion Criteria:

• have any eye conditions

Related Conditions & MeSH terms

• Chronobiology Disorders
• Circadian Rhythm Disorders
• Enuresis
• Enuresis, Nocturnal
• Ganglion
• Ganglion Cysts
• Nocturnal Enuresis
• Urinary Incontinence

Locations

Country	Name	City	State
Turkey	Bakircay University	Izmir

Sponsors (1)

Lead Sponsor	Collaborator
Izmir Bakircay University

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Difference in ganglion cell thickness in enuretic children	Normal values in RNFL measurements on OCT 75 (lowest)-107.2 (highest)	Baseline