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NCT ID: NCT01366742 Active, not recruiting - Clinical trials for Human Papillomavirus

Natural History of HPV From Infection to Neoplasia in Adolescents and Young Women

Start date: December 1987
Phase: N/A
Study type: Observational

The natural history of human papillomavirus (HPV) is most likely influenced by both innate and adaptive mucosal immunity. More specifically, we hypothesize that Toll like receptors (TLR) play an important role in cervical innate immunity to HPV through secretions of proinflammatory, chemotactic and anti-viral cytokines. Up-regulated TLR expression will also result in activation of dendritic cells and T cells that in turn will promote a T helper (Th) l like response through secretion of several cytokines and consequently, the induction of a successful cell mediated immune (CMI) response.