Effects of Narratives on Demand for Low and High Ventilated Cigarettes and Substitution for Alternative Products

Cigarette Smoking Clinical Trial

Official title:

Effects of Narratives on Demand for Low and High Ventilated Cigarettes and Substitution for Alternative Products

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05487625
• Other study ID #: IRB #22-432
• Secondary ID: 5P01CA217806
• Status: Recruiting
• Phase: N/A
• Start date: August 8, 2022
• Est. completion date: May 31, 2024

Study information

• Verified date: January 2024
• Source: Virginia Polytechnic Institute and State University
• Contact: Roberta Freitas Lemos, Ph.D.
• Phone: 5405262106
• Email: rflemos[@]vtc.vt.edu
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study will investigate the effects of narratives on demand for low and high ventilated cigarettes and substitution for alternative products in the Experimental Tobacco Marketplace.

Description:

An important aim of tobacco control is to reduce demand for the most harmful products. One product feature that could be changed to benefit public health is cigarette filter ventilation. A recent review examined the effects of cigarette filter ventilation and concluded that filter ventilation, by changing how a cigarette burns, yields more mutagens and carcinogens, and results in greater puff volume and possibly depth of inhalation, which has led to increases in peripheral lung adenocarcinomas. This study will use a novel method, the Experimental Tobacco Marketplace (ETM), to compare the impact of a narrative and a factsheet on the negative consequences of filter ventilation on tobacco product purchases. High-ventilated cigarette smokers will complete multiple scenarios in the ETM.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 100
• Est. completion date: May 31, 2024
• Est. primary completion date: May 31, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 21 Years and older

Eligibility

Inclusion Criteria:

• Provide informed consent

• Be at least 21 years of age or older

• Provide a breath sample for measuring carbon monoxide (CO = 8 ppm)

• Stable tobacco use patterns for at least three months

• Be willing to sample the study cigarettes (high- and low-ventilated cigarettes)

• Report smoking a high-ventilated cigarette (>= 20% ventilation)

• Report smoking at least 10 cigarettes per day

Exclusion Criteria:

• Have plans to move out of the area

• Have a serious or unstable physical or mental health condition

• Taking a tobacco cessation medication or medication that interferes with nicotine metabolism, motivation or reinforcement

• Report concrete, immediate plans to alter/quit using their usual nicotine products at the beginning of the study

Related Conditions & MeSH terms

• Cigarette Smoking

Intervention

Behavioral:
• High-ventilated cigarette alone
High-ventilated cigarettes are the only available cigarettes in the Experimental Tobacco Marketplace which increases in price across trials. Other nicotine/tobacco products are available in the Experimental Tobacco Marketplace at market price. Note that all participants will complete all the specified conditions.
• Low-ventilated cigarette alone
Low-ventilated cigarettes are the only available cigarettes in the Experimental Tobacco Marketplace which increases in price across trials. Other nicotine/tobacco products are available in the Experimental Tobacco Marketplace at market price. Note that all participants will complete all the specified conditions.
• High- and low-ventilated cigarette with high-ventilated cigarettes increasing in price
High- and low ventilated cigarettes are available in the Experimental Tobacco Marketplace with high-ventilated cigarettes increasing in price across trials. Other nicotine/tobacco products are available in the Experimental Tobacco Marketplace at market price. Note that all participants will complete all the specified conditions.
• Low- and high-ventilated cigarette with high-ventilated cigarettes increasing in price
Low- and high-ventilated cigarettes are available in the Experimental Tobacco Marketplace with low-ventilated cigarettes increasing in price across trials. Other nicotine/tobacco products are available in the Experimental Tobacco Marketplace at market price. Note that all participants will complete all the specified conditions.
• Usual, high- and low-ventilated cigarette with usual cigarettes increasing in price.
Usual cigarette, low- and high-ventilated cigarettes are available in the Experimental Tobacco Marketplace with usual cigarettes increasing in price across trials. Other nicotine/tobacco products are available in the Experimental Tobacco Marketplace at market price. Note that all participants will complete all the specified conditions.

Locations

Country	Name	City	State
United States	Addiction recovery Research center	Roanoke	Virginia

Sponsors (3)

Lead Sponsor	Collaborator
Virginia Polytechnic Institute and State University	National Cancer Institute (NCI), University of Minnesota

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Nicotine/tobacco products substitution	Participants will complete purchasing trials in an Experimental Tobacco Marketplace (ETM) with cigarettes increasing in price (cigarette type depending on condition). Other product prices will remain at market price. The degree to which other nicotine/tobacco products substitute for usual, high-and-low ventilated cigarettes prices will be assessed.; To obtain estimates of substitution of price-constant products in the different ETM conditions, the investigators will use ordinary least squares regression to model the relationship of the price-manipulated product to predict total quantity purchased of the price-constant product.	1 day
Primary	Cigarette demand	Participants will complete purchasing trials in an Experimental Tobacco Marketplace (ETM) with cigarettes increasing in price (cigarette type depending on condition). Other product prices will remain at market price. The degree to which other nicotine/tobacco products substitute for usual, high-and-low ventilated cigarettes prices will be assessed.; To obtain dependent measures of demand, participants' purchasing of the price-manipulated commodity in the ETM task will be fit to a modified exponential equation to quantify the relationship between the price of each commodity and purchasing: Q=Q0*10k(exp(-aQ0C)-1) where Q is purchasing of the commodity, C is the price, Q0 is the derived initial purchasing without cost constraints (demand intensity), k is the span of the function in logarithmic units, and a is the demand elasticity.	1 day