Brain Nicotine Receptor Density & Response to Nicotine Patch

Status Completed

Clinical Trial Summary

Even though the health risks and societal costs of cigarette smoking are well-known, roughly 19.8% of American adults continue to smoke. While most smokers endorse a desire to quit, very few (< 5%) will actually quit in a given year without treatment, and only about 20-25% achieve abstinence after 6 months or more of effective treatment. Therefore, there continues to be a vital need to improve outcomes for cigarette smokers seeking treatment. Current first-line medications for Tobacco Dependence include nicotine replacement therapies (such as the patch, gum, lozenge, nasal spray, and inhaler), varenicline HCl (Chantix), and bupropion HCl (Zyban), with the current standard of care in most treatment settings being to choose specific medications based primarily on availability, ease of use, and patient preference. The goal of the proposed research is to improve the delivery of smoking cessation treatment by determining if pre-treatment nicotine receptor density in cigarette smokers is associated with smoking cessation outcome with the standard nicotine patch taper. The study's main hypothesis is that cigarette smokers with less pre-treatment upregulation of nicotine receptors will have a greater likelihood of quitting smoking from a standard course of nicotine patch treatment than smokers with more up-regulation of these receptors. Positron emission tomography (PET) will be used to test this hypothesis.

Clinical Trial Description

n/a

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

Cigarette Smoking

Clinical Trial Details

NCT number	NCT01526005
Study type	Observational
Source	Brentwood Biomedical Research Institute
Contact
Status	Completed
Phase	Phase 3
Start date	March 2012

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04043728` - Addressing Psychological Risk Factors Underlying Smoking Persistence in COPD Patients: The Fresh Start Study	N/A
Completed	`NCT04284813` - Families With Substance Use and Psychosis: A Pilot Study	N/A
Active, not recruiting	`NCT02643914` - Control Systems Approach to Predicting Individualized Dynamics of Nicotine Cravings	N/A
Recruiting	`NCT02422914` - Benefits of Tobacco Free Cigarette	N/A
Active, not recruiting	`NCT02629679` - Sports, Education and Consumption of Substances in Adolescents	N/A
Completed	`NCT02385227` - Characterization of Biomarkers of Tobacco Exposure, Urge-to-Smoke Following Exclusive and Dual Ad Lib Use of Electronic Cigarettes	N/A
Completed	`NCT02218281` - Developing a Smartphone App With Mindfulness Training for Teen Smoking Cessation	N/A
Completed	`NCT01199380` - Behavioral Activation Intervention for Smoking Cessation in Smokers With Depressive Symptoms	Phase 2
Completed	`NCT01692353` - Cardiovascular Disease Biomarkers in Smokers and Moist Snuff Consumers	N/A
Completed	`NCT00802919` - Varenicline for Cognitive Deficits and Cigarette Smoking in Schizophrenia - Efficacy and Predictors	Phase 4
Completed	`NCT00756704` - The Effectiveness of Smoking Cessation Guidelines in the Emergency Department	N/A
Completed	`NCT01081119` - Brief Voluntary Alcohol and Drug Intervention for Middle School Youth	Phase 2
Completed	`NCT00682474` - School Nurse-Delivered Smoking Cessation Intervention	Phase 2/Phase 3
Completed	`NCT05520775` - Semaglutide for Alcohol Use Disorder	Phase 2
Completed	`NCT03743532` - E-Cigarettes and Financial Incentives to Promote Tobacco Harm Reduction Among Adults Accessing Shelter Services	N/A
Terminated	`NCT03840694` - Nicotine Withdrawal and Reward Processing: Connecting Neurobiology to Real-world Behavior	N/A
Completed	`NCT06032793` - Effects of Deep Breathing Exercise on Pulmonary Function, Perceived Stress and Physical Fitness.	N/A
Terminated	`NCT03326128` - High Dose Bupropion for Smoking Cessation - Pilot Study	Phase 2
Recruiting	`NCT03218670` - Your Health in On Click	N/A
Completed	`NCT02538042` - Strengthening Instrumental Extinction to Prevent Smoking Relapse (VLNCCue)	N/A