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Clinical Trial Summary

follicular unit extraction as a method of hair transplantation in cicatricial alopecia


Clinical Trial Description

The study will include 20 patients with cicatrical alopecia.Patients will be randomly assigned into two groups:Group (A):include ten patients will undergo (FUE) alone. Group (B): include ten patients will undergo(FUE) and (PRP).3-Surgical technique: - Preoperative Investigations including complete blood count, coagulation profile and hepatitis viral markers. 1-Group(A): will undergo (FUE) - Washing the scalp with antiseptic shampoo before the procedure. - Tumuscentanaesthesia:The donor area is anesthetized with a lidocaine 1% solution diluted with 20 cc saline in addition to adrenaline. - Creation of micropunches(0.7-1 mm) using micromotor. - After removal of the punch,the follicular unit is extracted with Jweler's forceps. - Extracted grafts are then placed on chilled saline gauze for maximum four hours until ready for transplantation. - The recipient area is prepared with rectangular scalpel blades 1mm or hypodermic blades 0.9 mm. - Implantation using fine tipped jweler's forceps. - Finally, receptor and donor areas will be softly cleansed with saline and crepe bandage is applied. 2-Group (B): FUE+PRP - The same procedure will be done but grafts will be placed in Prp solution. - Prp session one week before transplantation then monthly for 3 monthes after (FUE). - Preparation of PRP - 10 cc blood will be aspirated in test tube contained a modified solution of anticoagulant,called acid-citrate-dextrose type (ACDA), in which the physiological pH will reached to preserve the platelet integrity. - The first spin of whole blood sample will be at 2500 rpm for 4 minutes - The second spin at 4000 for 20 minutes for obtained plasma. - Platelets are separated as a pellet at the bottom of the tube from platelet-poor plasma (PPP) above. The platelet-rich pellet is resuspended in remaining amount of plasma. The resulting suspension is used as PRP. - Prp is injected in the recipient area. 4-Follow up: - Follow up clinically by digital photographs and trichoscopy 1 week after operation, after 3 months and after 6 months. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04472715
Study type Interventional
Source Alexandria University
Contact
Status Completed
Phase N/A
Start date January 5, 2020
Completion date December 5, 2020

See also
  Status Clinical Trial Phase
Completed NCT05076006 - Dual JAK1/TYK2 Inhibitor for Cicatricial Alopecia Phase 2
Recruiting NCT05549934 - Ritlecitinib for Cicatricial Alopecia Phase 2